一、临床药理学与治疗学 (2023年第114卷第3期)

September 2023 - Volume 114 - Issue 3 (2023年9月第114卷第3期)
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2023/114/3

Editorial（社论）
1. 新的治疗方式：未来就在现在
(Novel Therapeutic Modalities: The Future is Now)
作者：Yewon Choi, Piet H. van der Graaf* (Merck & Co., Inc, USA; Certara, UK)

Perspective（视角）
1. 疫情期间的成功与机遇：从疫苗开发角度的思考与启示
(Successes and Opportunities during the Pandemic: Reflections and Revelations from a Vaccine Development Perspective)
作者：Penny M. Heaton, Kavitha Palaniappan* (The Janssen Pharmaceutical Companies of Johnson & Johnson, Singapore; Duke-NUS Medical School, Centre of Regulatory Excellence, Singapore)
2. 药物开发的未来机遇：美国临床药理学和治疗学学会的药物计量学和药代动力学社区愿景
(Future Opportunities in Drug Development: American Society for Clinical Pharmacology and Therapeutics Pharmacometrics and Pharmacokinetics Community Vision)
作者：Jackson Burton (Clinical Pharmacology and Pharmacometrics, Biogen Inc., USA)
3. 依库珠单抗在移植相关血栓性微血管病基因治疗中采用模型引导的精确给药
(Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies)
作者：Sonata Jodele (Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, USA)

White Paper（白皮书）
1. 基于腺相关病毒载体的基因治疗产品开发的模型引导方法和创新临床试验设计：白皮书
(Model-Informed Approaches and Innovative Clinical Trial Design for Adeno-Associated Viral Vector-Based Gene Therapy Product Development: A White Paper)
作者：Amitava Mitra (Clinical Pharmacology, Kura Oncology, USA)
2. CAR-T和TCR-T细胞疗法最佳开发的临床药理学和定量药理学方面的最佳实践和考虑因素：一个行业视角
(Best Practices and Considerations for Clinical Pharmacology and Pharmacometric Aspects for Optimal Development of CAR-T and TCR-T Cell Therapies: An Industry Perspective)
作者：Hardik Mody, Vijay V. Upreti* (Clinical Pharmacology, Genentech, USA; Clinical Pharmacology, Modeling & Simulation, Amgen, USA)

Reviews（综述）
1. 靶向蛋白降解物的临床转化
(Clinical Translation of Targeted Protein Degraders)
作者：Nikki R. Kong*, Lyn H. Jones* (Center for Protein Degradation, Dana-Farber Cancer Institute, USA)
2. 细胞和基因治疗项目进入临床领域的思考
(Considerations for Cell and Gene Therapy Programs Entering the Clinical Space)
作者：Geoffrey A. Walford (Merck & Co., Inc., USA)
3. 数字治疗作为一种新的治疗方式：一份从临床药理学角度的综述
(Digital Therapeutics as a New Therapeutic Modality: A Review from the Perspective of Clinical Pharmacology)
作者：Benjamin Ribba (Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Switzerland)
4. 基于CRISPR的治疗发展中的临床药理学和转化考虑
(Clinical Pharmacology and Translational Considerations in the Development of CRISPR-Based Therapies)
作者：Ahmed M. Abdelhady, Mark Stroh* (Intellia Therapeutics, Inc., USA)

Systematic Review（系统综述）
1. COVID-19的预后因素：国际药物流行病学学会认可的总括性综述
(Prognostic Factors of COVID-19: An Umbrella Review Endorsed by the International Society for Pharmacoepidemiology)
作者：Grammati Sarri (Cytel, UK)

Research（研究）
1. 医生对FDA决定加速批准阿杜那单抗治疗阿尔茨海默病的看法
(Physician Perspectives on the Food and Drug Administration's Decision to Grant Accelerated Approval to Aducanumab for Alzheimer's Disease)
作者：Sanket S. Dhruva, Aaron S. Kesselheim* (Section of Cardiology, Department of Medicine, San Francisco Veterans Affairs Medical Center, USA; Program on Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, USA)
2. 评估与新型肿瘤药物和生物制品的初始儿科研究计划相关信息差距
(Assessing Information Gaps Associated with Initial Pediatric Study Plans for New Oncology Drug and Biological Products)
作者：Daphne Guinn (Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, USA)

Articles（文章）
1. 使用生理学建模评估静脉注射或肿瘤内给药后对V937溶瘤病毒的临床反应
(Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically-Based Modeling)
作者：Zinnia P. Parra-Guillen, Tomoko Freshwater* (Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Spain; Quantitative Pharmacology and Pharmacometrics Immune/Oncology (QP2-I/O), Merck & Co., Inc., USA)
2. 描述活体生物治疗产品的细胞动力学-药效学关系以支持微生物组药物开发的定量系统药理学模型
(A Quantitative Systems Pharmacology Model Describing the Cellular Kinetic-Pharmacodynamic Relationship for a Live Biotherapeutic Product to Support Microbiome Drug Development)
作者：Marissa Renardy, Lucia Wille* (Applied BioMath LLC, USA; Takeda Development Center Americas, Inc., USA)
3. 使用肿瘤生长抑制-存活模型框架在阿替利珠单抗治疗胆道癌的随机II期试验中的早期决策
(Early Decision Making in a Randomized Phase II Trial of Atezolizumab in Biliary Tract Cancer Using a Tumor Growth Inhibition-Survival Modeling Framework)
作者：Colby S. Shemesh (Clinical Pharmacology, Genentech Inc., USA)
4. 机器学习应用程序可用于识别卡铂、紫杉烷和贝伐珠单抗治疗的卵巢癌患者中高血压的种系标志物
(Machine Learning Application Identifies Germline Markers of Hypertension in Patients With Ovarian Cancer Treated With Carboplatin, Taxane, and Bevacizumab)
作者：Maurizio Polano, Giuseppe Toffoli* (Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico, Italy)
5. CAR-T细胞动力学特征的生物分析方法：PCR测定和基质的比较
(Bioanalytical Methods for Characterization of CAR-T Cellular Kinetics: Comparison of PCR Assays and Matrices)
作者：Madhan Masilamani (Department of Clinical Pharmacology, Pharmacometrics, Disposition, and Bioanalysis, Bristol Myers Squibb, USA)
6. 促炎细胞因子介导ADME基因在三维人肝球体中表达的机制、功能和临床研究
(Mechanistic, Functional, and Clinical Aspects of Pro-inflammatory Cytokine Mediated Regulation of ADME Gene Expression in 3D Human Liver Spheroids)
作者：Katharina Klöditz, Magnus Ingelman-Sundberg* (Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Sweden)
7. 二氢吡啶类钙通道抑制剂相关的缺氧：VigiBase药物警戒研究
(Hypoxia Associated With Dihydropyridine Calcium Channel Inhibitors: A Pharmacovigilance Study in VigiBase)
作者：Basile Chrétien, Richard Descamps* (Department of Pharmacology, Caen University Hospital, France)
8. 健康成年受试者中细胞色素p450介导的大麻素-药物相互作用的评估
(Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants)
作者：Sumit Bansal, Jashvant D. Unadkat* (Department of Pharmaceutics, School of Pharmacy, University of Washington, USA)
9. T1dCteGui：一个用户友好的临床试验改进工具，通过利用基于AI/ML的合成患者群体来优化T1D预防研究
(T1dCteGui: A User-Friendly Clinical Trial Enrichment Tool to Optimize T1D Prevention Studies by Leveraging AI/ML Based Synthetic Patient Population)
作者：Mike Pauley, Jagdeep T. Podichetty* (Critical Path Institute, USA)
10. 同时使用磺脲类药物和DPP-4抑制剂的药理学异质性和严重低血糖的风险：基于群体的队列研究
(Pharmacologic Heterogeneity and Risk of Severe Hypoglycemia with Concomitant Use of Sulfonylureas and DPP-4 Inhibitors: Population-Based Cohort Study)
作者：Jenny Dimakos, Antonios Douros* (Department of Medicine, McGill University, Canada)

二、药理学评论

September 2023 - Volume 75 - Issue 5 (2023年9月第75卷第5期)
https://pharmrev.aspetjournals.org/content/75/5

Review Articles（综述文章）
1. ABCB1和 ABCG2在血脑屏障中的调控：改善脑内药物递送的潜在新靶点
(ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery)
作者：Julia A. Schulz (Department of Pharmaceutical Sciences, College of Pharmacy (J.A.S., B.B.), Sanders-Brown Center on Aging and Department of Pharmacology and Nutritional Sciences, College of Medicine (A.M.S.H.), University of Kentucky, Kentucky)
2. β−抑制蛋白类：结构、功能、生理学和药理学展望
(β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives)
作者：Arrestins (Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Maryland)
3. 内源性大麻素系统作为治疗靶点的利弊：30年后的经验教训
(Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years)
作者：Mauro Maccarrone (Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy)
4. 内质网结构和钙动力学的药理学调节：对神经退行性疾病的重要性
(Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases)
作者：Ilmari Parkkinen (Neuroscience Center, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Finland)
5. 细胞SUMOylation调控的悖论：生物分子固化物的作用？
(Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?)
作者：Xiaodong Cheng (Department of Integrative Biology & Pharmacology and Texas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas)
6. Myc家族和转移抑制因子NDRG1：创新疗法靶向关键分子的相互作用
(The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics)
作者：Zhao Deng (Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Australia)
7. 胆汁形成：发展一种新的范式
(Hepatic Bile Formation: Developing a New Paradigm)
作者：Norman B. Javitt (NYU Grossman School of Medicine, Division of Gastroenterology and Hepatology, USA)
8. 细胞外囊泡异质性及其对再生医学应用的影响
(Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications)
作者：Simonides Immanuel van de Wakker (Department of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, The Netherlands)

三、先进药物输送评论 (2023年第200卷)

September 2023 - Volume 200 (2023年9月第200卷)
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/200/suppl/C

Review article（综述文章）
1. 用于体内RNA递送的脂质纳米颗粒及其未来应用的突破性技术
(Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications)
作者：Michaela Jeong, Hyukjin Lee* (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Korea)
2. 基于纳米材料的眼科给药
(Nanomaterial-based ophthalmic drug delivery)
作者：Guocheng Xie, Sisi Lin, Feng Wu*, Jinyao Liu* (Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China)
3. 用于长效药物递送系统的聚合物原位成形库
(Polymeric in situ forming depots for long-acting drug delivery systems)
作者：Anjali K. Pandya, Vandana B. Patravale* (Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, India)
4. 天然胃肠道粘液：研究与药物、药物载体和细菌相互作用的关键特征和技术
(Native gastrointestinal mucus: Critical features and techniques for studying interactions with drugs, drug carriers, and bacteria)
作者：Chia-Ming Wang, Rebecca L. Carrier* (Department of Bioengineering, Northeastern University, USA)
5. 用组学方法评估纳米颗粒的生物反应
(Omics approaches for the assessment of biological responses to nanoparticles)
作者：Yasmin Abdelkader, Richard LeDuc* (Unity Health Toronto – St. Michael’s Hospital, University of Toronto, Canada; Children’s Hospital Research Institute of Manitoba, Canada)
6. 长效缓释抗逆转录病毒疗法在治疗和预防HIV感染方面的研究进展
(Advances in long-acting slow effective release antiretroviral therapies for treatment and prevention of HIV infection)
作者：Mohammad Ullah Nayan, Benson Edagwa*, Howard E. Gendelman* (Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, USA)
7. 眼后段给药的新时代：系统性、细胞靶向、基于树状大分子疗法的转化
(A new era in posterior segment ocular drug delivery: Translation of systemic, cell-targeted, dendrimer-based therapies)
作者：Rangaramanujam M. Kannan (Center for Nanomedicine, Johns Hopkins University School of Medicine, USA)
8. 眼部给药智能材料研究进展
(Recent advances of smart materials for ocular drug delivery)
作者：Xiaojun Wang, Wei Wei* (Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, China; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, China)
9. 面对抗真菌药物的耐药性、耐受性和持久性：药物靶点发现和递送系统的进展
(Confronting antifungal resistance, tolerance, and persistence: Advances in drug target discovery and delivery systems)
作者：Lei Chen, Xinying Xue* (State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, China; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, China)
10. 靶向细胞器的小分子在体内的药物递送模式
(The in vivo drug delivery pattern of the organelle-targeting small molecules)
作者：Zhao Fang, Hao Chen* (Molecular Imaging Center, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China)
11. 凝血组在肿瘤免疫微环境中的作用
(The role of coagulome in the tumor immune microenvironment)
作者：Riajul Wahab, Md Mahedi Hasan, Taslim A. Al-Hilal* (Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, USA)
12. 多糖水凝胶平台作为脂质体和细胞外囊泡的合适载体可应用于皮肤
(Polysaccharide hydrogel platforms as suitable carriers of liposomes and extracellular vesicles for dermal applications)
作者：Leila Pourtalebi Jahromi, Gregor Fuhrmann* (Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, Pharmaceutical Biology, Germany)
13. 靶向神经细胞器用于中枢神经系统药物开发
(Targeted to neuronal organelles for CNS drug development)
作者：Zheng Ying*, Xuechu Zhen* (Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, China)
14. 量子点在再生医学、癌症医学和传染病方面的诊疗应用
(Theranostics applications of quantum dots in regenerative medicine, cancer medicine, and infectious diseases)
作者：Hiroshi Yukawa*, Yoshinobu Baba* (Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Japan)
15. 与目标接触有关的细胞内时空代谢
(Intracellular spatiotemporal metabolism in connection to target engagement)
作者：Jingwei Zhang, Guangji Wang* (State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, China)
16. 靶向给药和控释的纳米药物制剂的发展
(Evolution of nanomedicine formulations for targeted delivery and controlled release)
作者：Sanyogitta Puri¹, Mariarosa Mazza¹*, J. Anand Subramony²* (1. Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, UK; 2. Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, Biologics Engineering, Oncology R&D, USA)
17. 聚乙二醇纳米颗粒与血液免疫系统的相互作用
(The interplay between PEGylated nanoparticles and blood immune system)
作者：Chen Guo, Jingxin Gou*, Xing Tang* (Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, China)
18. 要么退出，要么死亡：基于肽和蛋白质的RNA治疗内体逃逸
(Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics)
作者：Alexander Klipp*, Michael Burger*, Jean-Christophe Leroux* (Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Switzerland)
19. 超分辨率显微镜在线粒体动力学疾病中的应用
(Application of super-resolution microscopy in mitochondria-dynamic diseases)
作者：Weiwei Zou, Dongmei Ji* (Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, China)
20. 病理组织微环境屏障调节纳米医学的研究进展
(Progress on the pathological tissue microenvironment barrier-modulated nanomedicine)
作者：Han Han, Ling Li* (State Key Laboratory of Natural Medicines, China Pharmaceutical University, China; Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, China)
21. 基于mRNA传递的基因编辑疗法
(Gene editing therapeutics based on mRNA delivery)
作者：Juliana Popovitz¹, Rohit Sharma², Niren Murthy²*, Kunwoo Lee¹ (1. GenEdit, 681 Gateway Blvd., USA; 2. Department of Bioengineering, University of California, USA)
22. 用于mRNA递送的工程纳米颗粒工具包
(Engineering nanoparticle toolkits for mRNA delivery)
作者：Bing Sun¹, Owen S. Fenton²*, Hao Song¹* (1. Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Australia; 2. Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA)
23. 粘膜屏障在疾病进展和传播中的作用
(The role of mucosal barriers in disease progression and transmission)
作者：Nicole A. Bustos, Caroline E. Wagner* (Department of Mechanical Engineering, Massachusetts Institute of Technology, USA; Department of Bioengineering, McGill University, Canada)
24. 通过生物材料辅助免疫工程绕过移植排斥反应的新兴策略：来自胰岛及其他领域的见解
(Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond)
作者：Samin Abbaszadeh, Bo Xiao* (Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Netherlands; State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, China)

四、药理学发展趋势 (2023年第44卷第9期)

September 2023 - Volume 44 - Issue 9 (2023年9月第44卷第9期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(22)X0010-2

Spotlight（聚焦）
1. CRISPR平铺屏幕揭示癌症表观遗传的“金发姑娘”状态
(CRISPR tiling screen reveals cancer epigenetic ‘Goldilocks’ state)
作者：Aleksia Barka¹, Rahul M. Kohli²*, Junwei Shi²* (1. Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, USA; 2. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, USA)
2. 同种异体血管病变中的Hedgehog信号传导：一个新的治疗靶点？
(Hedgehog signalling in allograft vasculopathy: a new therapeutic target?)
作者：Jasmine Rowell, Tessa Crompton* (UCL Great Ormond Street Institute of Child Health, UK)

Opinion（意见）
1. 人工智能驱动的治疗靶点发现
(AI-powered therapeutic target discovery)
作者：Frank W. Pun, Alex Zhavoronkov* (Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong, China)
2. 铜稳态与铜死亡在心血管疾病治疗中的作用
(Copper homeostasis and cuproptosis in cardiovascular disease therapeutics)
作者：Lifang Yang, Jun Ren* (Department of Anesthesiology, Xi’an Children Hospital, China; Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, China)

Feature Review（特征综述）
1. GABAA受体作为治疗抑郁症情感和认知症状的靶点
(GABAA receptors as targets for treating affective and cognitive symptoms of depression)
作者：Bernhard Luscher, Uwe Rudolph* (Department of Biology, Pennsylvania State University, University Park, USA; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, USA)

Reviews（综述）
1. PI3K的异构体选择性靶向：是时候考虑新的机会了？
(Isoform-selective targeting of PI3K: time to consider new opportunities?)
作者：Davide Cirillo, Marc Nazaré* (Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Campus Berlin-Buch, Germany)
2. NET靶向治疗：效果、局限性及提高治疗效果的潜在策略
(NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy)
作者：Caio Santos Bonilha*, Fernando de Queiroz Cunha* (Center for Research in Inflammatory Diseases, University of Sao Paulo, Brazil)

Drug of the Month（本月最佳药物）
1. Fezolinetant治疗更年期潮热和盗汗
(Fezolinetant for menopausal hot flashes and night sweats)
作者：Ismael González-García* (Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Spain)

五、药理学与治疗学 (2023年第249卷)

September 2023 - Volume 249 (2023年9月第249卷)
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/249/suppl/C

Review article（综述文章）
1. 稳定神经屏障—疼痛治疗的一种新方法
(Stabilizing the neural barrier – A novel approach in pain therapy)
作者：Ann-Kristin Reinhold, Heike L. Rittner* (University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Germany)
2. 用于癌症治疗的自噬抑制剂：小分子和纳米药物
(Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines)
作者：Jian-Li Chen, Xuan Wu, Xiao-Ming Zhu* (State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, China)
3. 以红细胞为中心的MFSD2B鞘氨醇-1-磷酸转运体的研究
(An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter)
作者：Shahrooz Ghaderi, Bodo Levkau* (Institute of Molecular Medicine III, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany)
4. 靶向PCSK9治疗心血管疾病
(Targeting PCSK9 to tackle cardiovascular disease)
作者：Sandra Hummelgaard, Kathrin Weyer* (Department of Biomedicine, Aarhus University, Denmark)
5. 视网膜和RPE脂质谱变化与ABCA4相关的Stargardt黄斑病有关
(Retina and RPE lipid profile changes linked with ABCA4 associated Stargardt's maculopathy)
作者：Mitra Farnoodian, Kapil Bharti* (Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institute of Health, USA)
6. 胆固醇在神经元和外周炎症中的共同作用
(The shared role of cholesterol in neuronal and peripheral inflammation)
作者：Scott B. Hansen* (Department of Molecular Medicine, UF Scripps, USA)
7. 通过靶向P-糖蛋白（ABCB1）克服癌症多药耐药性（MDR）的策略：最新综述
(Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): An updated review)
作者：Jinyun Dong* (The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China)
8. 钾稳态—临床背景下的生理学和药理学
(Potassium homeostasis – Physiology and pharmacology in a clinical context)
作者：Ralph Kettritz*, Johannes Loffing* (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Institute of Anatomy, University of Zurich, Switzerland)
9. 酪氨酸激酶和免疫检查点抑制剂在低危转移性肾细胞癌中的应用：不给糖就捣蛋？
(Tyrosine kinase and immune checkpoints inhibitors in favorable risk metastatic renal cell carcinoma: Trick or treat?)
作者：Martina Catalano, Giandomenico Roviello* (Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Italy)
10. 血管痉挛性心绞痛：过去、现在和未来
(Vasospastic angina: Past, present, and future)
作者：Zuowen He¹, Xin Xu², Dao Wen Wang¹* (1. Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China; 2. Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, China)
11. 丙酸血症并发症的病理生理机制
(Pathophysiological mechanisms of complications associated with propionic acidemia)
作者：Hannah Marchuk, Xiaoxin Chen* (Sarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University, USA; Surgical Research Lab, Department of Surgery, Cooper University Healthcare and Cooper Medical School of Rowan University, USA)
12. SGLT2抑制剂对糖尿病肾病啮齿动物模型中肾脏影响的系统综述
(A systematic review on renal effects of SGLT2 inhibitors in rodent models of diabetic nephropathy)
作者：Aqsa Ashfaq, Martin C. Michel* (Dept. of Pharmacology, University Medical Center, Johannes Gutenberg University, Germany)
13. 腺苷受体信号作为肺纤维化的驱动因素
(Adenosine receptor signalling as a driver of pulmonary fibrosis)
作者：Emily Cash, Amanda L. Tatler* (Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, UK)
14. 三冠王：NO, CO和H2S在癌细胞生物学中的作用
(The Triple Crown: NO, CO, and H2S in cancer cell biology)
作者：Palak P. Oza, Khosrow Kashfi* (Department of Molecular, Cellular and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, USA)
15. 靶向α-突触核蛋白聚集的药物干预可引发快速动眼睡眠行为障碍和帕金森病的早期发展
(Pharmacological interventions targeting α-synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease)
作者：Lida Du*, Wing-ho Yung* (Institute of Molecular Medicine & Innovative Pharmaceutics, Qingdao University, China; School of Biomedical Sciences, The Chinese University of Hong Kong, China)
16. GABA能调节睡眠-清醒状态
(GABAergic modulation of sleep-wake states)
作者：Yo Oishi, Yuki C. Saito, Takeshi Sakurai* (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan)

六、药物 (2023年第83卷第13-14期)

（一）September 2023 - Volume 83 - Issue 13 (2023年9月第83卷第13期)
https://link.springer.com/journal/40265/volumes-and-issues/83-13

Leading Article（社评）
1. 抗心律失常药物治疗的最新进展
(Recent Advances in Antiarrhythmic Drug Therapy)
作者：Arnela Saljic, Dobromir Dobrev* (Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark)

Review Article（综述文章）
1. 胰岛素Tregopil：一种超快速口服重组人胰岛素类似物：糖尿病的临床前和临床进展
(Insulin Tregopil: An Ultra-Fast Oral Recombinant Human Insulin Analog: Preclinical and Clinical Development in Diabetes Mellitus)
作者：Shashank Joshi, Subramanian Loganathan* (Joshi Clinic and Lilavati Hospital, India; Biocon Biologics Ltd, Biocon House, Semicon Park, Electronic City Phase 2, India)
2. 抗肿瘤坏死因子药物和新型生物制剂（维得利珠单抗和乌司奴单抗）在预防和治疗克罗恩病术后复发中的作用
(Anti-TNF Agents and New Biological Agents (Vedolizumab and Ustekinumab) in the Prevention and Treatment of Postoperative Recurrence After Surgery in Crohn’s Disease)
作者：Javier P. Gisbert* (Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain)

Original Research Article（原创研究文章）
1. 直接抗病毒药物与慢性丙型肝炎患者心律失常和传导障碍的风险：一项法国全国队列研究
(Direct-Acting Antivirals and the Risk of Arrhythmias and Conduction Disorders in Patients with Chronic Hepatitis C: A French Nationwide Cohort Study)
作者：Laurent Lam* (Sorbonne Université, INSERM, Institut Pierre Louis d’Épidémiologie et de Santé Publique, France)

Adis Drug Evaluation（Adis药物评估）
1. 瑞德西韦：在COVID-19中的应用综述
(Remdesivir: A Review in COVID-19)
作者：Hannah A. Blair* (Springer Nature, New Zealand)

AdisInsight Report（AdisInsight报告）
1. Sovateltide：首次获批
(Sovateltide: First Approval)
作者：Susan J. Keam (Springer Nature, New Zealand)
2. Sulbactam/Durlobactam：首次批准
(Sulbactam/Durlobactam: First Approval)
作者：Susan J. Keam (Springer Nature, New Zealand)

（二）September 2023 - Volume 83 - Issue 14 (2023年9月第83卷第14期)
https://link.springer.com/journal/40265/volumes-and-issues/83-14

Therapy in Practice（治疗实践）
1. 坏疽性脓皮病：治疗方案
(Pyoderma Gangrenosum: Treatment Options)
作者：Joachim Dissemond* (Department of Dermatology, Venerology and Allergology, University of Essen, Germany)

Review Article（综述文章）
1. 口腔面部疼痛的药理学治疗
(Pharmacological Management of Orofacial Pain)
作者：Marcela Romero-Reyes* (Brotman Facial Pain Clinic, School of Dentistry, University of Maryland, USA)

Systematic Review（系统综述）
1. GLP-1受体激动剂治疗心力衰竭患者的临床结果：随机对照试验的系统评价和Meta分析
(Clinical Outcomes with GLP-1 Receptor Agonists in Patients with Heart Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials)
作者：Huilei Zhao, Peng Yu* (Department of Anesthesiology, The Third Hospital of Nanchang, China; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, China)

Adis Drug Evaluation（Adis药物评估）
1. 桦树皮提取物：大疱性表皮松解症的研究进展
(Birch Bark Extract: A Review in Epidermolysis Bullosa)
作者：Young-A Heo* (Springer Nature, New Zealand)

AdisInsight Report（AdisInsight报告）
1. 利特昔替尼：首次获批
(Ritlecitinib: First Approval)
作者：Hannah A. Blair (Springer Nature, New Zealand)
2. Delandistrogene Moxeparvovec：首次批准
(Delandistrogene Moxeparvovec: First Approval)
作者：Sheridan M. Hoy (Springer Nature, New Zealand)
3. Epcoritamab：首次批准
(Epcoritamab: First Approval)
作者：James E. Frampton (Springer Nature, New Zealand)
4. Rozanolixizumab：首次批准
(Rozanolixizumab: First Approval)
作者：Sheridan M. Hoy (Springer Nature, New Zealand)

七、药理学研究 (2023年第195卷)

September 2023 - Volume 195 (2023年9月第195卷)
https://www.sciencedirect.com/journal/pharmacological-research/vol/195/suppl/C

Review Articles（综述文章）
1. 五味子科二苯并环二烯木脂素：植物化学、构效关系及保肝作用的研究进展
(Dibenzocyclooctadiene lignans from the family Schisandraceae: A review of phytochemistry, structure-activity relationship, and hepatoprotective effects)
作者：Shi-qi Liu, Yu-pei Yang, Wei Wang* (TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, China)
2. Resolvin D2及其受体GPR18在心血管和代谢疾病中的作用：一个有前景的生物标志物和治疗靶点
(Resolvin D2 and its receptor GPR18 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target)
作者：Mengmeng Zhao, Juanjuan Qin* (Department of Cardiology, Renmin Hospital of Wuhan University, China; Department of Geriatrics, Zhongnan Hospital of Wuhan University, China)
3. 芍药总苷治疗5种炎症性关节炎的疗效和安全性：系统综述和Meta分析
(Efficacy and safety of total glucosides of paeony in the treatment of 5 types of inflammatory arthritis: A systematic review and meta-analysis)
作者：Kailin Yang¹, Liuting Zeng², Jinwen Ge¹* (1. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, China; 2. Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, China)
4. 神经介肽U系统：治疗肥胖和暴饮行为的药理学意义
(The neuromedin U system: Pharmacological implications for the treatment of obesity and binge eating behavior)
作者：Luca Botticelli, Emanuela Micioni Di Bonaventura, Carlo Cifani* (School of Pharmacy, Pharmacology Unit, University of Camerino, Italy)
5. 硒补充剂对血糖控制的影响：一项GRADE评估的系统综述和随机对照试验的剂量-反应Meta分析
(Selenium supplementation effect on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials)
作者：Mahdi Vajdi¹, Shirin Hassanizadeh¹, Mohammad Bagherniya²* (1. Student Research Committee, Isfahan University of Medical Sciences, Iran; 2.Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran )
6. 外泌体穿梭的非编码RNA在胃肠道癌症中的新作用：从细胞间串扰到临床应用
(Emerging role of exosome-shuttled noncoding RNAs in gastrointestinal cancers: From intercellular crosstalk to clinical utility)
作者：Bihan Xia, Kai Deng* (Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, China)
7. Treg细胞：调节性T细胞在抑郁症中的关键作用
(Treg cell: Critical role of regulatory T-cells in depression)
作者：Xiao Gao, Chunxia Wang* (Department of Geriatrics, Qingdao Mental Health Center, China)
8. 氨基酸有助于适应性产热。对最近治疗代谢紊乱的药物作用机制，我们有了新的见解。
(Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging)
作者：Chiara Ruocco, Enzo Nisoli* (Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Italy)
9. 电子尼古丁输送系统（ENDS）：一种便捷的吸烟方式？
(Electronic nicotine delivery systems (ENDS): A convenient means of smoking?)
作者：Mariaelvina SALA* (Institute of Neuroscience, CNR-Milan Unit, c/o Bldg. U28, University of Milano-Bicocca, Italy)
10. 载脂蛋白B与低密度脂蛋白胆固醇在动脉粥样硬化性心血管疾病风险评估中的比较
(Apolipoprotein B compared with low-density lipoprotein cholesterol in the atherosclerotic cardiovascular diseases risk assessment)
作者：Federica Galimberti, Manuela Casula* (IRCCS MultiMedica, Sesto S. Giovanni, Italy)
11. 改善1型糖尿病青少年患者血糖控制的新疗法
(New therapies towards a better glycemic control in youths with type 1 diabetes)
作者：Roque Cardona-Hernandez¹, Klemen Dôvc², Chiara Mameli³* (1. Division of Pediatric Endocrinology. Hospital Sant Joan de Déu, Spain; 2. Faculty of Medicine, University of Ljubljana, Slovenia; 3. Department of Pediatrics, V. Buzzi Children's Hospital, Italy)
12. 治疗结节性硬化症的范式转变：依维莫司的有效性
(Paradigm shift in the treatment of tuberous sclerosis: Effectiveness of everolimus)
作者：Roberto Previtali, Savina Mannarino* (Pediatric Neurology Unit, Buzzi Children’s Hospital, Italy; Pediatric Cardiology Unit, Department of Pediatric, Buzzi Children’s Hospital, Italy)
13. 器官芯片模型在药物开发过程中预测人体药代动力学特征的应用
(The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development)
作者：Marit Keuper-Navis, Evita van de Steeg* (Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), the Netherlands)

Research article（研究文章）
1. 用小分子抑制剂靶向GLI1和GLI2抑制GLI1依赖性转录和肿瘤生长
(Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth)
作者：Luisa Maresca, Fabrizio Manetti* (Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Italy; Dept. of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy)
2. HPV E7驱动的ALKBH5通过调节PAK5的m6A修饰促进宫颈癌症进展
(HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5)
作者：Fu-Chun Huo¹, Jie Mou²*, Dong-Sheng Pei¹* (1. Department of Pathology, Xuzhou Medical University, 209 Tong-shan Road, China; 2. Jiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical University, China)
3. 石蒜碱通过调节上皮间质转化和β-catenin信号传导抑制乳腺癌的恶性程度
(Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial mesenchymal transition and β-catenin signaling)
作者：Yanfang Sun* (College of Life Sciences and Medicine, Zhejiang Sci-Tech University, China)
4. 肿瘤内皮细胞衍生的循环细胞外囊泡劫持局部和全身抗肿瘤免疫反应：mTOR/G-CSF通路的作用
(Circulating extracellular vesicles derived from tumor endothelial cells hijack the local and systemic anti-tumor immune response: Role of mTOR/G-CSF pathway)
作者：Malvina Koni, Tatiana Lopatina, Maria Felice Brizzi* (Department of Medical Sciences, University of Turin, Italy)
5. 小胶质细胞感觉并抑制癫痫神经元过度兴奋
(Microglia sense and suppress epileptic neuronal hyperexcitability)
作者：Yang Hu, Xinjian Zhu* (Department of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Medical School of Southeast University, China)
6. ENPP2抑制剂通过重塑肠道屏障功能和肠道菌群组成，促进AOM/DSS诱导的结直肠癌小鼠的增殖
(ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition)
作者：Junling Yan¹, Wenting Duan², Jialin Duan¹*, Jiankang Li¹* (1. Xi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, China; 2. Department of Cardiology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, China)
7. 阿托西班和具有保胎功效的天然产品mundulone联合治疗可阻止小鼠早产直至足月分娩
(Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy)
作者：Shajila Siricilla, Jennifer L. Herington* (Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, USA)
8. 肠道间充质基质细胞通过调节免疫反应和肠道生态失调，减少C57BL/6J小鼠结肠炎相关癌症
(Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL/6J mice modulating the immune response and gut dysbiosis)
作者：Laura Hidalgo-García, Antonio Jesús Ruiz-Malagon, Alba Rodríguez-Nogales*, Julio Gálvez* (Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Spain)
9. 敲除Sema4D可通过抑制AOX1表达减轻肝纤维化
(Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression)
作者：Lifu Wang, Zhongdao Wu* (Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, China; Department of Parasitology, Zhongshan School of Medicine, China)
10. 结直肠癌肝转移中的染色质可及性动力学：单细胞分辨率下的肝嗜性
(Chromatin accessibility dynamics in colorectal cancer liver metastasis: Uncovering the liver tropism at single cell resolution)
作者：Shasha Li*, Dong Wang* (Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology & Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, Medical Center for Comprehensive Weight Control, The Third Affiliated Hospital of Sun Yat-Sen University, China; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, China)

八、抗病毒研究 (2023年第217卷)

September 2023 - Volume 217 (2023年9月第217卷)
https://www.sciencedirect.com/journal/antiviral-research/vol/217/suppl/C

Research article（研究文章）
1. 靶向hDLG1-Tax-1蛋白-蛋白相互作用鉴定抗HTLV-1的小分子抗病毒药物
(Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction)
作者：Sibusiso B. Maseko¹, Alexander N. Volkov²*, Jean-Claude Twizere¹* (1. Laboratory of Viral Interactomes, Unit of Molecular Biology of Diseases, GIGA Institute, University of Liege, Belgium; 2. VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Belgium)
2. 小分子抗病毒化合物集合（SMACC）：一个全面、高度整理的数据库，用于支持广谱抗病毒药物分子的发现
(Small molecule antiviral compound collection (SMACC): A comprehensive, highly curated database to support the discovery of broad-spectrum antiviral drug molecules)
作者：Holli-Joi Martin, Alexey V. Zakharov* (UNC Eshelman School of Pharmacy, University of North Carolina, USA; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, USA)
3. 先进的虚拟筛查能够发现宿主靶向和广谱抗病毒药物
(Advanced virtual screening enables the discovery of a host-targeting and broad-spectrum antiviral agent)
作者：Garri Chilingaryan, Roza Izmailyan, Hovakim Zakaryan* (Laboratory of Antiviral Drug Discovery, Institute of Molecular Biology of NAS, Armenia)
4. 肝GABA能系统促进小鼠肝巨噬细胞M2极化并介导HBV复制
(The hepatic GABAergic system promotes liver macrophage M2 polarization and mediates HBV replication in mice)
作者：Ziyou Bao,  Wei-Yang Lu* (Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Science, Shandong University, China; Department of Physiology and Pharmacology, Robarts Research Institute, University of Western Ontario, Canada)
5. HCMV复制必需的pUL51中亮氨酸-拉链基序的鉴定和抗病毒开发的潜在靶标
(Identification of a leucine-zipper motif in pUL51 essential for HCMV replication and potential target for antiviral development)
作者：Clotilde Muller, Sébastien Hantz* (Univ. Limoges, France)
6. Ceragenins通过在激活宿主免疫应答时增加I型干扰素的表达和释放，对SARS-CoV-2表现出抗病毒活性
(Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response)
作者：Krzysztof Fiedoruk¹,Robert Bucki¹*, Krzysztof Pyrć²* (1. Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Poland; 2. Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Poland)
7. 2022年美国鸟类和哺乳动物高致病性禽流感(H5N1)病毒分支2.3.4.4b抗病毒药物敏感性研究
(Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022)
作者：Ha T. Nguyen, Larisa V. Gubareva* (Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), USA)
8. 阿贝西利通过抑制pul97介导的SAMHD1磷酸化来限制HCMV复制
(Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1)
作者：Georgios Vavouras Syrigos, Michael Schindler* (Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Germany)
9. 通过CRISPR设计的T4噬菌体纳米颗粒为快速开发流感粘膜疫苗提供了一个多功能平台
(T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines)
作者：Mengling Li, Pan Tao* (State Key Laboratory of Agricultural Microbiology, Key Laboratory of Prevention & Control for African Swine Fever and Other Major Pig Diseases, Ministry of Agriculture and Rural Affairs, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, China)
10. Janus激酶抑制调节戊肝病毒感染
(Janus kinase-inhibition modulates hepatitis E virus infection)
作者：Volker Kinast*, Eike Steinmann* (Department of Medical Microbiology and Virology, Carl von Ossietzky University Oldenburg, Germany; Department for Molecular and Medical Virology, Faculty of Medicine, Ruhr University Bochum, Germany)
11. 跗关节接触阿托伐醌可抑制埃及伊蚊传播基孔肯雅病毒，但不能抑制寨卡病毒的传播
(Tarsal exposure to atovaquone inhibits chikungunya virus transmission by Aedes aegypti mosquitoes, but not the transmission of Zika virus)
作者：Leen Delang, Leen Delang* (KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Belgium)
12. 会议报告：2023年3月13日至17日在法国里昂举行的第36届国际抗病毒研究会议
(Meeting report: 36th International Conference on Antiviral Research in Lyon, France – March 13–17, 2023)
作者：Jessica R. Spengler* (Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, USA)
13. 硫氧噻唑[3,4-a]喹唑啉衍生物抑制人巨细胞病毒碱性核酸酶
(Thioxothiazolo[3,4-a]quinazoline derivatives inhibit the human cytomegalovirus alkaline nuclease)
作者：Tianyu Zhang, Wolfram Brune* (Leibniz Institute of Virology (LIV), Germany)
14. 新型siRNA疗法证明了其对SARS-CoV-2多变异株的疗效
(Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2)
作者：Ellen Bowden-Reid, Chantelle Ahlenstiel* (Kirby Institute, UNSW Sydney,Australia)
15. SIRT2的抑制通过细胞凋亡和坏死促进人巨细胞病毒感染的外周血单核细胞的死亡
(Inhibition of SIRT2 promotes death of human cytomegalovirus-infected peripheral blood monocytes via apoptosis and necroptosis)
作者：Jennifer Cheung, Gary C. Chan* (Department of Microbiology & Immunology, SUNY Upstate Medical University, USA)
16. SARS-CoV-2 nsp13双酮酸抑制剂阻断病毒复制
(Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication)
作者：Angela Corona¹, Valentina Noemi Madia², Roberta Costi²*, Enzo Tramontano¹* (1. Dipartimento di Scienze della vita e dell'ambiente. Università degli Studi di Cagliari, Cittadella Universitaria di Monserrato, Italy; 2. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci-Bolognetti, “Sapienza” Università di Roma, Italy)
17. 钠/胆汁酸共转运体(NTCP)作为乙型肝炎病毒和家猫肝炎病毒的进入受体的保守使用
(Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus)
作者：Maya Shofa, Akatsuki Saito* (Department of Veterinary Science, University of Miyazaki, Japan)
18. PRO-2000通过干扰刺突肝素结合表现出SARS-CoV-2抗病毒活性
(PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding)
作者：Evelien Vanderlinden* (KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Belgium)
19. 神经氨酸酶抑制剂AV5080在甲型和乙型流感病毒中的耐药性分析
(Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses)
作者：Andrei A. Ivashchenko¹, Elena A. Govorkova²*, Alexandre V. Ivachtchenko¹* (1. ChemDiv, USA; 2. Department of Infectious Diseases, St. Jude Children's Research Hospital, USA)
20. 紫草素是一种炎症小体抑制剂，可以抑制Epstein-Barr病毒的再激活
(Shikonin, an inhibitor of inflammasomes, inhibits Epstein-Barr virus reactivation)
作者：Chloé Borde, Alexandre E. Escargueil*, Vincent Maréchal* (Sorbonne Université, France)
21. 兽医科学和生物防御BSL-3网络研究联盟(RAV3N)：网络起源和第 I 阶段活动报告
(Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N): Report on network origin and phase I activities)
作者：Carrie L. Hunt, Kurt Zuelke* (Global Health Research Complex, Division of Research, Texas A&M University, USA)
22. CVB3诱导和劫持心脏miR-19a/19b，通过靶向病毒基因组rdrp编码区促进病毒复制
(Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region)
作者：Yingchun Wu, Yan Yue*, Sidong Xiong* (Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, China)

九、英国药理学杂志 (2023年第180卷第17-18期)

（一）September 2023 - Volume 180 - Issue 17 (2023年9月第180卷第17期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/17

Editorial（社论）
1.《英国药理学杂志》近期变化：扩大范围，提高作者和编辑经验
(Recent changes in the British Journal of Pharmacology: widening scope and improving author and editor experience)
作者：Andreas Papapetropoulos, Péter Ferdinandy* (Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Greece; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Hungary)

Research Article（研究文章）
1. α7-烟酸胆碱受体对含周细胞视网膜毛细血管的调节
(Alpha 7-nicotinic cholinoceptor regulation of pericyte-containing retinal capillaries)
作者：Kaicheng Wu, Chunhui Jiang*, Xujiao Zhou* (Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, China)
2. 非依赖MrgprA3的瞬时受体电位离子通道TRPA1和TRPV1被氯喹激活的分子机制
(Molecular mechanisms of MrgprA3-independent activation of the transient receptor potential ion channels TRPA1 and TRPV1 by chloroquine)
作者：Tabea C. Fricke, Andreas Leffler* (Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Germany)
3. 利用Szeto-Schiller 31靶向线粒体应激可预防实验性腹主动脉瘤：内质网应激串扰
(Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress)
作者：Miquel Navas-Madroñal, Cristina Rodriguez*, María Galán* (Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Spain)
4. Jumonji结构域蛋白3 (JMJD3)在肾纤维化中促进髓系成纤维细胞活化和巨噬细胞极化
(Jumonji domain-containing protein-3 (JMJD3) promotes myeloid fibroblast activation and macrophage polarization in kidney fibrosis)
作者：Changlong An, Yanlin Wang* (Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, USA)
5. 内皮TRPV4和KCa3.1通道偶联在调节冠状动脉血管张力中的功能作用
(Functional role of coupling the endothelial TRPV4 and KCa3.1 channels in regulating coronary vascular tone)
作者：Aiqin Mao, Xin Ma* (Wuxi School of Medicine, Jiangnan University, China)
6. TGF-β/miR-9阳性调控环在乳腺癌中促进肿瘤启动细胞的扩张和活性
(A positive TGF-β/miR-9 regulatory loop promotes the expansion and activity of tumour-initiating cells in breast cancer)
作者：Yichen Liu, Tao Xi* (School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, China)
7. 体外脓毒症上调Nociceptin/Orphanin FQ受体在人T细胞而非B细胞上的表达和功能
(In vitro sepsis up-regulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells)
作者：Mark F. Bird, David G. Lambert* (Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, UK)

（二）September 2023 - Volume 180 - Issue 18 (2023年9月第180卷第18期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/18

Research Article（研究文章）
1. 和厚朴酚是sirtuin-3的诱导剂，对非甾体抗炎药诱导的胃黏膜线粒体病理、细胞凋亡和炎症组织损伤具有保护作用
(Honokiol, an inducer of sirtuin-3, protects against non-steroidal anti-inflammatory drug-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury)
作者：Subhashis Debsharma, Uday Bandyopadhyay* (Division of Infectious Diseases and Immunology, CSIR-Indian Institute of Chemical Biology, India)
2. 卡芬太尼是一种在μ阿片受体上的β-抑制因子偏向激动剂
(Carfentanil is a β-arrestin-biased agonist at the μ opioid receptor)
作者：Nokomis Ramos-Gonzalez, Eamonn Kelly* (School of Physiology, Pharmacology and Neuroscience, University of Bristol, UK)
3. 氧化可溶性鸟苷酸环化酶引起酒精中毒性小鼠勃起功能障碍
(Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice)
作者：Miguel A. Olivencia, Esther O'Shea*, Francisco Perez-Vizcaino* (Departamento de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense, Spain)
4. 慢性酒精通过促进神经炎症引起的机械性异常疼痛：酒精诱发神经性疼痛的小鼠模型
(Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol-evoked neuropathic pain)
作者：Vittoria Borgonetti¹, Nicoletta Galeotti¹*, Marisa Roberto²* (1. Department of Neuroscience, Psychology, Drug Research, and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Italy; 2. Department of Molecular Medicine and Neuroscience, The Scripps Research Institute, USA)
5. 高盐通过血管紧张素II-AT1和前列腺素E2-EP1系统的相互作用诱导认知障碍
(High salt induces cognitive impairment via the interaction of the angiotensin II-AT1 and prostaglandin E2-EP1 systems)
作者：Hisayoshi Kubota, Akihiro Mouri* (Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Japan)
6. 补体成分C3作为降低高血压肾病患者蛋白尿的新靶点
(Complement component C3 as a new target to lower albuminuria in hypertensive kidney disease)
作者：Marlies Bode, Ulrich O. Wenzel* (III. Department of Medicine, University Hospital Hamburg-Eppendorf, Germany)
7. 脂联素受体激动剂AdipoAI通过抑制牙龈成纤维细胞诱导的巨噬细胞迁移来减轻糖尿病大鼠的牙周炎
(The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast-induced macrophage migration)
作者：Wei Qiu, Buling Wu*, Fuchun Fang* (Department of Stomatology, Nanfang Hospital, Southern Medical University, China)

十、临床药代动力学 (2023年第62卷第9期)

September 2023 -Volume 62 - Issue 9 (2023年9月第62卷第9期)
https://link.springer.com/journal/40262/volumes-and-issues/62-9

Review Article（综述文章）
1. 肌注曲安奈德（Kenalog®）疗效之谜
(Enigma of Intramuscular Triamcinolone Acetonide (Kenalog®) Efficacy)
作者：Sheeva Shahinfar* (Texas A&M University School of Medicine, USA)

Systematic Review（系统综述）
1. 基于AGREE II工具的治疗药物监测指南的现状与质量评价
(Status and Quality of Guidelines for Therapeutic Drug Monitoring Based on AGREE II Instrument)
作者：Zhan-Miao Yi, Xinya Li, Rongsheng Zhao* (Department of Pharmacy, Peking University Third Hospital, China)
2. 抗逆转录病毒药物在老年HIV感染者中的药代动力学：一项系统综述
(Pharmacokinetics of Antiretroviral Drugs in Older People Living with HIV: A Systematic Review)
作者：Thainá Toledo, Rita Estrela* (Sérgio Arouca National School of Public Health, ENSP Fiocruz, Brazil)

Original Research Article（原创研究文章）
1. 静脉注射[14C]二氟哌林在健康受试者和血液透析患者体内的药代动力学、代谢和排泄
(Pharmacokinetics, Metabolism, and Excretion of Intravenous [14C]Difelikefalin in Healthy Subjects and Subjects on Hemodialysis)
作者：Jeffrey G. Stark, Robert H. Spencer* (Worldwide Clinical Trials, USA; Cara Therapeutics, Inc., USA)
2. 通过迭代PBPK模型开发和改进揭示阿比特龙吸收和处置动力学的复杂性
(Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement)
作者：Eleanor Jing Yi Cheong, Eric Chun Yong Chan* (Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore)
3. 西妥昔单抗靶向介导的药代动力学与转移性结直肠癌患者无进展生存期的关系
(Relationship Between Cetuximab Target-Mediated Pharmacokinetics and Progression-Free Survival in Metastatic Colorectal Cancer Patients)
作者：Sarah Lobet, David Ternant* (Inserm UMR 1069, Nutrition Croissance et Cancer (N2C), Tours University, France; EA4245 Transplantation, Immunologie, Inflammation (T2i), Tours University, France)
4. 群体靶点介导的药代动力学/药效学模型用于评估健康成年人SPI-62暴露和肝脏11β-羟基类固醇脱氢酶1型（HSD-1）抑制作用
(Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults)
作者：Nan Wu, Guohua An* (Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, USA)
5. 基于群体药代动力学模型的儿童肾移植受者肾功能对麦考酚酸总清除率的影响
(Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling)
作者：Yan Rong, Tony K. L. Kiang* (Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Canada)
6. 通过微量探针药物测定CYP3A和CYP2C19活性可准确预测健康成人伏立康唑清除率
(CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults)
作者：Amin Muhareb, Gerd Mikus* (Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Germany)
7. 鼻用艾氯胺酮在有和没有减鼻充血制剂预处理的变应性鼻炎患者以及有和没有鼻腔皮质类固醇预处理的健康受试者中的药代动力学
(Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment)
作者：Peter Zannikos* (Janssen R&D, USA)