一、临床药理学与治疗学 (2024年第116卷第2期)

August 2024 - Volume 116 - Issue 2 (2024年8月第116卷第2期)
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2024/116/2

Editorial
1. 模型引导的药物开发反思
Reflections on Model-Informed Drug Development
Lawrence J. Lesko* (University of Florida, USA)
Perspective
2. 美国食品药品监督管理局模型引导药物开发会议计划：从试点到路径
The US Food and Drug Administration's Model-Informed Drug Development Meeting Program: From Pilot to Pathway
Rajanikanth Madabushi* (US Food and Drug Administration, USA)
White Paper
3. 行业考虑事项—为FDA模型引导药物开发 (MIDD) 配对会议计划做准备
Considerations for Industry—Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program
Gerald R. Galluppi,  Jack Cook* (Sumitomo Pharma America, USA; A2-Ai LLC, USA)
Tutorial
4. 为培训科学家在模型引导药物开发中的现代课程：FDA资助培训监管科学家进展报告
A Modern Curriculum for Training Scientists in Model-Informed Drug Development: Progress Report on FDA Grant to Train Regulatory Scientists
Jeffrey S. Barrett* (Critical Path Institute, USA)
Review
5. 基于干扰素的最优治疗不再使慢性乙型肝炎的临床治愈遥不可及：基于新兴临床数据的循证综述
Optimal Treatment Based on Interferon No Longer Makes Clinical Cure of Chronic Hepatitis B Far Away: An Evidence-Based Review on Emerging Clinical Data
Yujing Li, Enqiang Chen* (West China Hospital, Sichuan University, China)
6. 2011至2023年美国癌症治疗批准中的精准患者选择生物标志物
Biomarkers for Precision Patient Selection in Cancer Therapy Approvals in the US, from 2011 to 2023
Yannan Nancy Dou,  Jian Wang* (AstraZeneca, USA)
7. 双特异性抗体开发的临床药理学策略：从FDA批准的肿瘤学双特异性抗体中学习
Clinical Pharmacology Strategies for Bispecific Antibody Development: Learnings from FDA-Approved Bispecific Antibodies in Oncology
KyoungSoo Lim,  Xu (Sue) Zhu* (BioPharmaceuticals R&D, AstraZeneca, USA)
Systematic Review
8. 酪氨酸激酶抑制剂用于肝细胞癌的风险与获益：随机对照试验的系统综述和Meta分析
Risk versus Benefit of Tyrosine Kinase Inhibitors for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Tania Payo-Serafín,  José L. Mauriz* (Universidad de León, Spain)
Research
Brief Report
9. 妊娠期间抑制PCSK9的单克隆抗体的安全性：VigiBase®中的不均衡性分析
Safety of Monoclonal Antibodies Inhibiting PCSK9 in Pregnancy: Disproportionality Analysis in VigiBase®
Roberta Noseda,  Alessandro Ceschi* (Ente Ospedaliero Cantonale, Switzerland)
10. 肾脏移植受者使用模型引导精准剂量的麦考酚酸莫非特，三年无排斥生存率更佳
Better Rejection-Free Survival at Three Years in Kidney Transplant Recipients With Model-Informed Precision Dosing of Mycophenolate MofetilClaire Villeneuve, Pierre Marquet* (Centre Hospitalier Universitaire de Limoges, France
11. 基于生理的药代动力学建模研究伏立康唑与尼马瑞韦/利托那韦在CYP2C19表型COVID-19患者中的疾病-药物-药物相互作用
Physiologically Based Pharmacokinetic Modeling to Investigate the Disease-Drug–Drug Interactions between Voriconazole and Nirmatrelvir/Ritonavir in COVID-19 Patients with CYP2C19 Phenotypes
Peile Wang,  Shuaibing Liu*,  Jing Yang* (the First Affiliated Hospital of Zhengzhou University, China)
12. 齐本坦可以与含有乙炔雌醇和左炔诺孕酮的避孕药联用：一项药代动力学药物-药物相互作用研究
Zibotentan Can Be Co-administered with Contraceptives Containing Ethinyl Estradiol and Levonorgestrel: A Pharmacokinetic Drug–Drug Interaction Study
Anne-Kristina Mercier* (R&D, Sweden)
13. 与慢性疼痛实验安慰剂效应相关的转录组特征
Transcriptomic Profiles Associated with Experimental Placebo Effects in Chronic Pain
Luana Colloca* (University of Maryland, USA)
14. CYP2D6、CYP2C9、CYP2C19和CYP3A5的药物基因组表型与退伍军人多药联用的关联
Association of Pharmacogenomic Phenotypes in CYP2D6, CYP2C9, CYP2C19, and CYP3A5 on Polypharmacy in Veterans
Linas Krulikas, Deepak Voora* (Durham VA Healthcare System, USA; Duke University Medical Center and Durham VA Healthcare System, USA)
15. 模型基础Meta分析在药物研究中的应用与质量：系统横断面分析与实际考虑
Application and Quality of Model-Based Meta-Analysis in Pharmaceutical Research: A Systematic Cross-Sectional Analysis and Practical Considerations
Zhirong Yang,  Ge Li*,  Feng Sun* (Shenzhen University of Advanced Technology, China; Tianjin University of Traditional Chinese Medicine, China; Peking University, China)
16. 食品药品监督管理局的信任度：一项全国性调查研究
Trust in the Food and Drug Administration: A National Survey Study
William B. Feldman* (Brigham and Women's Hospital, USA)
17. 通过与定量系统药理学模型的上下文统一优化双特异性T细胞引导剂的临床转化
Optimizing Clinical Translation of Bispecific T-cell Engagers through Context Unification with a Quantitative Systems Pharmacology Model
Xiaozhi Liao, Yanguang Cao* (University of North Carolina at Chapel Hill, USA)
18. 急性心肌梗死后2型糖尿病患者的临床结果：钠-葡萄糖共转运体2抑制剂与非使用者的比较
Clinical Outcomes in Type 2 Diabetes Patients After Acute Myocardial Infarction: A Comparison of Sodium–Glucose Cotransporter 2 Inhibitors vs. Non-Users
Hsin-Fu Lee, Lai-Chu See* (New Taipei City Municipal Tucheng Hospital, Taiwan, China; Chang Gung University, Taiwan, China)
19. 米瑞库珠单抗在中重度活动性溃疡性结肠炎患者中的暴露-反应关系：随机II期和III期研究
Mirikizumab Exposure–Response Relationships in Patients with Moderately-to-Severely Active Ulcerative Colitis in Randomized Phase II and III Studies
Stuart Friedrich, Xin Cindy Zhang* (Eli Lilly and Company, USA)
20. 三维思考：在高风险人群中筛查药物-药物-药物相互作用的自我和外部控制方法
Thinking Three-Dimensionally: A Self- and Externally-Controlled Approach to Screening for Drug–Drug–Drug Interactions Among High-Risk Populations
Emily K. Acton* (University of Pennsylvania, USA)
21. 发现和模型引导药物开发：一种控制释放形式的非消旋阿米舒必利，减少血浆暴露但在大脑中实现药效生物等效性
Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain
Seth C. Hopkins* (Sumitomo Pharma America, Inc., USA)
22. 沙库必利/缬沙坦在射血分数降低的心力衰竭和共存的终末期肾病患者中的长期结果
Long-Term Outcomes of Sacubitril/Valsartan in Heart Failure with Reduced Ejection Fraction and Coexisting End-Stage Renal Disease
Wan-Ying Lin, Bu-Yuan Hsiao* (Taipei Medical University Hospital, Taiwan, China)

二、药理学评论

（本刊为双月刊，每两月更新一次，详见2024年9月更新）

三、先进药物输送评论 (2024年第211卷)

August 2024 - Volume 209 (2024年8月第211卷)
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/211/suppl/C

Review article（综述文章）
1. 针对肿瘤中的细菌代谢物进行癌症治疗：针对肿瘤相关细菌的替代方法
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria
Guofeng Ji, Wantong Song* (Xuanwu Hospital, Capital Medical University, China; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China)
2. 再生医学应用中ECM生物材料临床转化的进展、挑战和未来方向
Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications
Héctor Capella-Monsonís, Stephen F. Badylak* (University of Pittsburgh, USA)
3. 难溶性药物的体内沉积
In vivo deposition of poorly soluble drugs
Zhaohuan Lou, Tonglei Li* (Zhejiang Chinese Medical University, China; Purdue University, USA)
4. 通过脂质纳米颗粒传递基于核酸的基因组编辑平台：临床应用
Delivery of nucleic acid based genome editing platforms via lipid nanoparticles: Clinical applications
Razan Masarwy, Inbal Hazan-Halevy*, Dan Peer* (Tel Aviv University, Israel)
5. 设计用于高效核靶向的纳米组装体
Nanoassemblies designed for efficient nuclear targeting
Michal Skowicki, Cora-Ann Schoenenberger*, Cornelia G. Palivan* (University of Basel, Switzerland)
6. 受线粒体内源性物质转运启发的纳米材料用于线粒体靶向基因传递
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery
Yi Wang, Hu-Lin Jiang* (China Pharmaceutical University, China)
7. 脑内腺相关病毒载体传递：技术进步和临床应用
Adeno-associated virus vector delivery to the brain: Technology advancements and clinical applications
Dezhuang Ye, Hong Chen* (Washington University in St. Louis, USA)
8. 调节细胞骨架的纳米材料及其治疗潜力
Cytoskeleton-modulating nanomaterials and their therapeutic potentials
Jinwon Park, Yu-Kyoung Oh* (Seoul National University, Republic of Korea)
9. 导航癌症治疗引起的心脏毒性：从病理生理学到治疗创新
Navigating cancer therapy induced cardiotoxicity: From pathophysiology to treatment innovations
Jessica Tetterton-Kellner, Juliane Nguyen* (University of North Carolina at Chapel Hill, USA)
10. 探索细胞来源的囊泡用于基因编辑有效载荷的短暂传递的潜力
Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
Kevin Leandro, Luís Pereira de Almeida* (University of Coimbra, Portugal)
11. 儿科、妊娠和老年药物开发中的模型引导药物开发：现状与未来
Model-informed drug development in pediatric, pregnancy and geriatric drug development: States of the art and future
Yue-E Wu, Wei Zhao* (Cheeloo College of Medicine, Shandong University, China)

四、药理学发展趋势 (2024年第45卷第8期)

August 2024 - Volume 45 - Issue 8 (2024年8月第45卷第8期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(23)X0009-1

Forum（论坛）
1. 针对铁死亡和癌症中的GPX4：化学策略与挑战
Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges
Jiao Liu* (The Third Affiliated Hospital of Guangzhou Medical University, China)
Opinion（观点）
2. 多种hERG通道阻断途径：对大分子的影响
Multiple hERG channel blocking pathways: implications for macromolecules
Bernd J. Zünkler* (Technische Universität Braunschweig, Germany)
Reviews（综述）
3. 针对GPCR的药物开发在皮肤科的进展
Advances in GPCR-targeted drug development in dermatology
Meng Wang, Chao Zhang* (Songjiang Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, China; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China)
4. BTK抑制剂：过去、现在和未来
BTK inhibitors: past, present, and future
Allison Cool, Justin Taylor* (Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, USA)
5. 镁在疾病治疗和预防中的应用：新兴机制与机遇
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities
Qi Gao, Onur Cil* (University of California, USA)
6. 通过精细化表型筛选创新癌症药物发现
Innovating cancer drug discovery with refined phenotypic screens
Zhenyi Wang, Pawel Swietach* (University of Oxford, UK)
7. PANoptosis：心血管疾病的新靶点
PANoptosis: a novel target for cardiovascular diseases
Qi Xiang, Ding-Sheng Jiang* (Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China)

五、药理学与治疗学 (2024年第260卷)

August 2024 - Volume 260 (2024年8月第260卷)
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/260/suppl/C

Review article（综述文章）
1. Mithramycin及其类似物：分子特征和抗肿瘤作用
Mithramycin and its analogs: Molecular features and antitumor action
José Portugal* (CSIC, Spain)
2. 髓母细胞瘤复发的机制洞察
Mechanistic insights into medulloblastoma relapse
Kendell Peterson, Jezabel Rodriguez-Blanco* (Medical University of South Carolina, USA)
3. UFMylation：一种整合的翻译后修饰，用于调节蛋白质稳态和细胞功能
UFMylation: An integral post-translational modification for the regulation of proteostasis and cellular functions
Xiaohui Wang, Guoqiang Xu* (Soochow University, China)
4. 皮肤屏障中的生物活性脂质在健康和疾病中的作用
Bioactive lipids in the skin barrier mediate its functionality in health and disease
Anna Nicolaou* (The University of Manchester, Manchester Academic Health Science Centre, UK)
5. 皮肤中的基质激肽：起源、效应和治疗潜力
Matrikines in the skin: Origin, effects, and therapeutic potential
Jonathan P. Sirois, Andrea Heinz* (University of Copenhagen, Denmark)
6. 癌症治疗相关心脏毒性的细胞间途径及其治疗意义：放疗的范例
Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: the paradigm of radiotherapy
Stella Logotheti* (National Technical University of Athens (NTUA), Greece)
7. 离子通道失调和细胞对帕金森病脑干应激起搏器中α-突触核蛋白的适应
Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of the parkinsonian brainstem
Wei-Hua Chiu, Joshua A. Goldberg* (New York University Grossman School of Medicine, USA; The Hebrew University of Jerusalem, Israel)
8. 聚焦与可塑性相关的基因：在健康和疾病中的当前见解
Spotlight on plasticity-related genes: Current insights in health and disease
Nicola Brandt, Franziska Köper, Anja U. Bräuer* (Carl von Ossietzky University Oldenburg, Germany)
9. 基于HDL的治疗：抗击病毒和细菌感染的有前景的前沿
HDL-based therapeutics: A promising frontier in combating viral and bacterial infections
Alankrita Rani, Gunther Marsche* (Medical University of Graz, Austria)
10. 早期生活逆境、精神病理学和新型药理策略
Early life adversities, psychopathologies and novel pharmacological strategies
Annamaria Cattaneo, Marco A. Riva* (Università degli Studi di Milano, Italy)

六、药物 (2024年第84卷第8期)

August 2024 - Volume 84 - Issue 8 (2024年8月第84卷第8期)
https://link.springer.com/journal/40265/volumes-and-issues/84-8

Current Opinion（当前观点）
1. 对传统抗风湿药物反应不足的类风湿关节炎患者使用生物制剂或Janus激酶抑制剂
Biologics or Janus Kinase Inhibitors in Rheumatoid Arthritis Patients Who are Insufficient Responders to Conventional Anti-Rheumatic Drugs
Ennio Giulio Favalli, Gabriella Maioli* (Università degli Studi di Milano, Italy)
Leading Article（重点文章）
2. 预防高危个体的类风湿关节炎：当前状况与未来展望
Prevention of Rheumatoid Arthritis in At-Risk Individuals: Current Status and Future Prospects
Task Toyoda, Kulveer Mankia* (University of Leeds, UK)
Review Article（综述文章）
3. 神经性吞咽障碍的新疗法和进展
New and Evolving Treatments for Neurologic Dysphagia
Ayodele Sasegbon, Shaheen Hamdy* (University of Manchester, UK)
4. 肥胖症的药物治疗作为减肥手术的辅助手段
Pharmacotherapy as an Augmentation to Bariatric Surgery for Obesity
Luděk Horváth, Martin Haluzík* (Institute for Clinical and Experimental Medicine, Czech Republic)
Systematic Review（系统综述）
5. 复方对乙酰氨基酚治疗背痛和骨关节炎：系统综述和Meta分析
Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses
Zhiying Cao, Stephanie Mathieson* (The University of Sydney, Australia)
AdisInsight Report（AdisInsight报告）
6. Mavorixafor：首次批准
Mavorixafor: First Approval
Sheridan M. Hoy
7. Zolbetuximab：首次批准
Zolbetuximab: First Approval
Susan J. Keam
8. Tovorafenib：首次批准
Tovorafenib: First Approval
Sohita Dhillon
9. Tarlatamab：首次批准
Tarlatamab: First Approval
Sohita Dhillon
10. Tunlametinib：首次批准
Tunlametinib: First Approval
Susan J. Keam

七、药理学研究 (2024年第206卷)

August 2024 - Volume 206 (2024年8月第206卷)
https://www.sciencedirect.com/journal/pharmacological-research/vol/206/suppl/C

Review Articles（综述文章）
1. 物质使用障碍与成瘾合作研究：西班牙方法作为模型
Substance use disorders and cooperative research on addictions: Spanish approach as a model
Jose Cárdenas-Quesada, Magí Farré* (Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina–IBIMA Plataforma Bionand, Avenida Severo Ochoa, Spain; Hospital Universitari Germans Trias I Pujol and Fundació Germans Trias I Pujol (HUGTiP-IGTP), Spain)
2. 消化道癌症中的RNA表观遗传修饰：朋友还是敌人？
RNA epigenetic modifications in digestive tract cancers: Friends or foes
Zekai Nian, Gangqiang Guo* (Wenzhou Medical University, China)
3. 转移RNA衍生小RNA在心血管疾病中的功能与治疗潜力：综述
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review
Kai Wang, Kun Wang* (Shandong Provincial Maternal and Child Health Care Hospital affiliated to Qingdao University, China)
4. 肌球蛋白轻链激酶这一重要心血管信号机制的作用与治疗靶点
Action and therapeutic targets of myosin light chain kinase, an important cardiovascular signaling mechanism
Qingzhi Ran¹, Aoshuang Li², Hengwen Chen¹* (1. Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, China; 2. Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, China)
5. 基质金属蛋白酶-9在心脏重塑和功能障碍中的作用及其作为心力衰竭潜在血液生物标志物的可能性
The role of matrix metalloproteinase-9 in cardiac remodeling and dysfunction and as a possible blood biomarker in heart failure
Keuri Eleutério Rodrigues, Alejandro Ferraz Prado* (Institute of Biological Sciences, Federal University of Para, Brazil)
6. 药物诱导毒性中依赖于Dynamin相关蛋白1的线粒体分裂的作用
Role of dynamin-related protein 1-dependent mitochondrial fission in drug-induced toxicity
Dan Li, Chengxiao Fu* (Hengyang Medical School, University of South China, China)
7. 铜代谢及其在糖尿病并发症中的作用：综述
Copper metabolism and its role in diabetic complications: A review
Dongkai Jia, Ying Xin* (The First Hospital of Jilin University, China; Jilin University, China)
8. 利用载肝素纳米平台改善组织工程产品的血液相容性
Improving hemocompatibility in tissue-engineered products employing heparin-loaded nanoplatforms
Nima Beheshtizadeh* (Tabriz University of Medical Sciences, Iran)
9. 心血管疾病：线粒体动力学与自噬交叉对话机制、新型程序化细胞死亡和巨噬细胞极化
Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation
Dandan Liu, Hewei Qin* (Henan University of Traditional Chinese Medicine, China)
10. 肾脏疾病和衰老中的Sirt3：从机制到潜在治疗
Sirtuin 3 in renal diseases and aging: From mechanisms to potential therapies
Xuan Peng, Nianqiao Gong* (Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China)
11. 针对Frizzleds的调节剂开发进展
Progress in the development of modulators targeting Frizzleds
Junlan Chuan, Zhenglin Yang* (Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, China; Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, China)
12. 心力衰竭中Nrf2介导的信号轴：潜在的药物受体
Nrf2 mediated signaling axis in heart failure: Potential pharmacological receptor
Pei-pei Cheng, Hua Zhou* (huguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China)
13. 心肌细胞程序性死亡在心血管疾病中的作用及新的治疗方法
Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches
Kexin Cai, Ying Zhang* (the First Hospital of China Medical University, China)
14. AGEs-RAGE轴的激活与调节：炎症病理学和治疗干预的意义——综述
Activation and modulation of the AGEs-RAGE axis: Implications for inflammatory pathologies and therapeutic interventions – A review
Mengzhou Zhou, Qian Wu* (National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, China)
15. 肉豆蔻酸：通过靶向多条信号通路预防和管理癌症的有效酚类二萜
Carnosic acid: an effective phenolic diterpenoid for prevention and management of cancers via targeting multiple signaling pathways
Xufei Chen, Cuntao Wei, Yangyang Bian* (College of Life Science, Northwest University, Xi’an, China)
16. 脆弱的调节性T细胞：免疫稳态中的叛徒？
Fragile Treg cells: Traitors in immune homeostasis?
Xiyu Song, Ruo Chen, Jiaxin Li, Jiejie Geng* (Fourth Military Medical University, China)
17. 癌症相关成纤维细胞介导对癌症抗EGFR疗法的抵抗
Cancer-associated fibroblasts mediate resistance to anti-EGFR therapies in cancer
Shuang Dai, Yingtong Liu, Xingchen Peng* (West China Hospital, Sichuan University, China)
18. 膀胱癌克隆演化与药物抗性之间的关系：基因组研究综述
Relationship between clonal evolution and drug resistance in bladder cancer: A genomic research review
Zhouting Tuo¹, Ying Zhang¹, Dengxiong Li², Yetong Wang³, Dechao Feng¹* (1. The Second Affiliated Hospital of Anhui Medical University, China; 2. West China Hospital, Sichuan University, China; 3. Army Medical University, China)
19. PI3K/AKT信号通路：抑郁症的分子机制与治疗潜力
PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression
Ningning Guo, Le Zhang* (Jining Medical University, China; Kunming University of Science and Technology, China)
20. 天冬酰胺：靶向肿瘤治疗中的关键代谢节点
Asparagine: A key metabolic junction in targeted tumor therapy
Xuan Wang, Weijian Gong, Juan Xu* (Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, China)
21. 细胞外囊泡与线粒体：在再生医学中的潜在作用
Extracellular vesicles meet mitochondria: Potential roles in regenerative medicine
Shujie Wu, Tao Yang, Zhichao Hao* (Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, China)
22. 脑胶质瘤：诊断和治疗问题及药物靶向纳米递送技术的前景
Brain gliomas: Diagnostic and therapeutic issues and the prospects of drug-targeted nano-delivery technology
Baoqin Song, Wanjun Liang* (Shandong First Medical University & Shandong Academy of Medical Sciences, China)
Research article（研究文章）
23. 整合素在血管周围脂肪组织的应力松弛中发挥作用
Integrins play a role in stress relaxation of perivascular adipose tissue
Stephanie W. Watts* (Michigan State University, USA)
24. 在肠道免疫组织化学和微生物群恢复中降低CR-HvKP感染的死亡风险
Lowering mortality risk in CR-HvKP infection in intestinal immunohistological and microbiota restoration
Hongyuhang Ni¹, Bill Kwan-Wai Chan², Sheng Chen²* (1. City University of Hong Kong, Hong Kong, China; 2. The Hong Kong Polytechnic University, Hong Kong, China)
25. Akkermansia muciniphila衍生的十五酸通过调节糖酵解增强胃癌对奥沙利铂的敏感性
Akkermansia muciniphila-derived pentadecanoic acid enhances oxaliplatin sensitivity in gastric cancer by modulating glycolysis
Qixuan Xu, Bo Wei* (Chinese PLA General Hospital, China)
26. ephrin-B2通过EphB2-MNK-eIF4E信号通路促进小鼠和人类的痛觉可塑性和超敏感性启动
ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans
Eric T. David, Theodore J. Price* (University of Texas at Dallas, USA)
27. 来自Rubia yunnanensis的环肽RA-V通过降低Nrf2的表达恢复Adagrasib对结直肠癌的活性
Cyclopeptide RA-V from Rubia yunnanensis restores activity of Adagrasib against colorectal cancer by reducing the expression of Nrf2
Zhuangzhuang Jiang, Shuqing Ye, Ninghua Tan* (China Pharmaceutical University, China)
28.Toll样受体4突变减轻肠道微生物群介导的高血压肾损伤
Toll-like receptor 4 mutation mitigates gut microbiota-mediated hypertensive kidney injury
Suravi Majumder¹, Sathnur B. Pushpakumar², Utpal Sen²* (1. University of Texas Health Science Center, USA; 2. University of Louisville, USA)
29. 通过牙髓干细胞衍生的细胞外囊泡转移miR-877–3p减轻神经元凋亡，并通过Bclaf1/P53信号通路促进脑缺血-再灌注损伤后的早期神经功能恢复
Transfer of miR-877–3p via extracellular vesicles derived from dental pulp stem cells attenuates neuronal apoptosis and facilitates early neurological functional recovery after cerebral ischemia–reperfusion injury through the Bclaf1/P53 signaling pathway
Yan Miao¹, Xin Liang², Ruxu Zhang¹* (1. The Third Xiangya Hospital, Central South University, China; 2. Beijing Shijitan Hospital, Capital Medical University, China)
30. DNMT和HDAC的双重抑制剂重塑结直肠癌的免疫微环境，并增强抗PD-L1治疗的疗效
Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy
Zhanbo Yang, Bizhu Chu*, Yuyang Jiang* (Shenzhen University Medical School, Shenzhen University, China)
31. Lactobacillus rhamnosus GG通过调节胆汁酸-FXR轴改善三氟氯噻吨引起的肝损伤
Lactobacillus rhamnosus GG ameliorates triptolide-induced liver injury through modulation of the bile acid-FXR axis
Shiping Hu, Bo Tang, Cheng Lu, Shiming Yang* (Xinqiao Hospital, Army Medical University, China)
32. 急性边缘系统连接性预测轻度创伤性脑损伤中的慢性认知功能：个性化差异结构协方差网络研究
Acute limbic system connectivity predicts chronic cognitive function in mild traumatic brain injury: An individualized differential structural covariance network study
Sihong Huang, Jun Liu* (The Second Xiangya Hospital, Central South University, China)
33. Faecalibacterium prausnitzii衍生的细胞外囊泡通过巨噬细胞代谢重编程减轻慢性结肠炎相关的肠道纤维化
Faecalibacterium prausnitzii-derived extracellular vesicles alleviate chronic colitis-related intestinal fibrosis by macrophage metabolic reprogramming
Ying Wang¹, Linjie Li², Ye Chen¹* (1. Shenzhen Hospital, Southern Medical University, China; 2. Nanfang Hospital, Southern Medical University, China)
34. Equisetin通过结合STAT3并抑制其活性在体内保护动脉粥样硬化
Equisetin protects from atherosclerosis in vivo by binding to STAT3 and inhibiting its activity
Yuting Yang, Jingzhu Wang, Yang Tian, Ming Chen* (Guangxi Normal University, China)
35. YEATS结构域含量蛋白GAS41通过与BRD2和介导复合体协同作用调节结直肠癌中的核形状
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer
Zhengmin Wang¹, Nan Zhao¹, Siwei Zhang², Nan Liu¹* (1. The First Hospital of Jilin University, China; 2. College of Basic Medical Sciences, Jilin University, China)
36. 钠-葡萄糖共转运体2抑制剂（SGLT2i）和其他抗糖尿病药物在阿尔茨海默病中的评估：一项基于人群的研究
Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease: A population-based study
Mar Garcia Zamora, Consuelo Cháfer Pericas* (Instituto de Investigación Sanitaria La Fe, Spain)
37. 新型NAD+-独立SIRT1激活剂的发现与特征
Discovery and characterization of a new class of NAD+-independent SIRT1 activators
Sara Della Torre, Paolo Ciana* (Università degli Studi di Milano, Italy)
38. RUNX1在结直肠癌亚型中的高表达通过抑制HMGCR加速恶性肿瘤的发展
High expression of RUNX1 in colorectal cancer subtype accelerates malignancy by inhibiting HMGCR
Zhilin Chang* (Beijing Tiantan Hospital, Capital Medical University, China)
39. 发现具有抗多发性骨髓瘤活性的新的FGF捕获小分子
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity
Sara Taranto¹, Riccardo Castelli², Arianna Giacomini¹*, Silvia Rivara²* (1. University of Brescia, Italy; 2. University of Parma, Italy)
40. Mtnr1b缺失通过VEGF信号通路破坏胎盘血管生成，导致胎儿生长受限
Mtnr1b deletion disrupts placental angiogenesis through the VEGF signaling pathway leading to fetal growth restriction
Likai Wang¹, Qi Han², Guoshi Liu¹* (1. China Agricultural University, China; 2. Beijing Friendship Hospital, Capital Medical University, China)
41. 增强肝脏L-天冬氨酸水平通过逆转糖皮质激素受体β介导的线粒体功能障碍抑制CCl4诱导的肝纤维化
Amplifying hepatic L-aspartate levels suppresses CCl4-induced liver fibrosis by reversing glucocorticoid receptor β-mediated mitochondrial malfunction
Rui Su, Hui-Ling Fu, Ling Huang* (Hainan University, China)

八、抗病毒研究 (2024年第228卷)

August 2024 - Volume 228 (2024年8月第228卷)
https://www.sciencedirect.com/journal/antiviral-research/vol/228/suppl/C

Review Article
1. 冠状病毒nsp15内切核酸酶：一个令人困惑的蛋白质和相关的抗病毒药物靶标
The coronavirus nsp15 endoribonuclease: A puzzling protein and pertinent antiviral drug target
Benjamin Van Loy, Lieve Naesens*（Rega Institute, Belgium)
Short communication
2. 用二氯乙酸（DCA）靶向糖代谢减少不同成熟阶段的大脑皮层祖细胞中寨卡病毒复制
Targeting glucose metabolism with dichloroacetate (DCA) reduces zika virus replication in brain cortical progenitors at different stages of maturation
Javier Gilbert-Jaramillo* (University of Oxford, UK)
Research Article
3. 融合蛋白方法整合抗病毒和抗炎活性，用于开发针对甲型流感病毒感染的新疗法
A fusion protein approach to integrate antiviral and anti-inflammatory activities for developing new therapeutics against influenza A virus infection
Guanxing Zhai, Weihui Fu, Jianqing Xu* (Fudan University, China)
4. α7烟碱受体激活减轻微胶质细胞中单纯疱疹病毒1型的感染
α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells
Shih-Heng Chen, Jerrel L. Yakel* (National Institutes of Health, USA)
5. 鉴定靶向拉沙病毒聚合酶的大环化合物
Identification of a macrocyclic compound targeting the lassa virus polymerase
Virginia Aida-Ficken, Mike Flint* (Centers for Disease Control and Prevention, USA)
6. 佐剂类型和给药途径对莱什曼虫源蜱传脑炎病毒样颗粒免疫原性的影响——一种重组疫苗候选物
Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate
Marta Zimna* (University of Gdansk and Medical University of Gdansk, Poland)
7. 枯草杆菌LjM2分泌的CPAVM1蛋白酶的抗流感活性
Anti-influenza activity of CPAVM1 protease secreted by Bacillus subtilis LjM2
Juan Li, Guangxun Meng* (Chinese Academy of Sciences, University of Chinese Academy of Sciences, China)
8. RBD设计增加SARS-CoV-2刺突疫苗诱导的功能抗体滴度
RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination
Thayne H. Dickey, Niraj H. Tolia* (National Institutes of Health (NIH), USA)
9. 基于生物工程策略的柔性纳米脂质体封装重组UL8-siRNA (r/si-UL8)抑制单纯疱疹病毒-1感染
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection
Jiawei Pei1, Ye Tian¹, Yamei Dang², Wei Ye², Airong Qian¹* (1. Northwestern Polytechnical University, China; 2. Airforce Medical University: Fourth Military Medical University, China)
10. 痘病毒预防新策略：具有强烈免疫反应的热稳定联合亚单位疫苗贴片
Novel strategy for Poxviridae prevention: Thermostable combined subunit vaccine patch with intense immune response
Yuan Wen, Feng Xue* (Nanjing Agricultural University, China)
11. 病毒感染与鞘脂代谢
Virus infection and sphingolipid metabolism
Jun Dai, Chan Ding* (Zunyi Medical University, China; Chinese Academy of Agricultural Sciences, China)
12. 2012-2013年和2019-2020年流感季节期间，接受巴洛沙韦、奥司他韦、拉尼米韦或扎那米韦治疗的感染A(H1N1)pdm09、A(H3N2)或B型流感病毒的儿童发热持续时间
Duration of fever in children infected with influenza A(H1N1)pdm09, A(H3N2) or B virus and treated with baloxavir marboxil, oseltamivir, laninamivir, or zanamivir in Japan during the 2012–2013 and 2019–2020 influenza seasons
Yuyang Sun* (Niigata University, Japan)
Short  Communication
13. 来特莫韦临床试验中遇到的巨细胞病毒遗传变异表型说明了基因分型验证的重要性
Phenotypes of cytomegalovirus genetic variants encountered in a letermovir clinical trial illustrate the importance of genotyping validation
Sunwen Chou* (Department of Veterans Affairs Medical Center, USA)
Research article
14. 登革病毒依赖于葡萄糖激酶活性和糖酵解，对NAD(H)生物合成抑制剂敏感
Dengue Virus dependence on glucokinase activity and glycolysis Confers Sensitivity to NAD(H) biosynthesis inhibitors
Eva Ogire, Olivier Diaz* (Univ Lyon, France)
15. HEX17(Neumifil)：具有广泛作用的鼻内呼吸生物治疗剂
HEX17(Neumifil): An intranasal respiratory biotherapeutic with broad-acting antiviral activity
Jane A. Potter* (Pneumagen Ltd., UK)
16. hnRNPAB通过干扰聚合酶活性抑制甲型流感病毒的感染
hnRNPAB inhibits Influenza A virus infection by disturbing polymerase activity
Linyue Lv, Xue Yang, Yuelan Zhang, Xiaoyan Ren, Bishi Fu* (Zhongnan Hospital, Wuhan University, China)
17. 以sgRNA N二级结构为靶标作为抑制SARS-CoV-2复制的一种方式
Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication
Agnieszka Baliga-Gil, Marta Soszynska-Jozwiak, Elzbieta Kierzek* (Polish Academy of Sciences, Poland)
Short Communication
18. CRISPR/Cas9介导的临床HSV-1分离株胸苷激酶基因组编辑鉴定F289S作为新型阿昔洛韦耐药突变
CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation
Shuxuan Zheng, Robert Jan Lebbink* (University Medical Center Utrecht, the Netherlands)
Research aeticle
19. 选择性TRPML2离子通道激动剂损害寨卡病毒复制
Zika virus replication is impaired by a selective agonist of the TRPML2 ion channel
Kerstin K. Schwickert, Eberhard Hildt* (Friedrich Schiller University, Germany; Paul-Ehrlich-Institut,  Germany)
20. 表征和非共价抑制SARS-cov-2 PLpro的K63去泛素化酶活性
Characterization and noncovalent inhibition of the K63-deubiquitinase activity of SARS-cov-2 PLpro
Xin Liu, Miao Zheng, Hongqing Zhang, Bo Feng, Jie Zheng* (Chinese Academy of Sciences, China)
21. 针对Spike蛋白新型同源三聚体腔的分子靶向减少SARS-CoV-2复制
Molecules targeting a novel homotrimer cavity of Spike protein attenuate replication of SARS-CoV-2
Alison Daniels¹, Monikaben Padariya², Umesh Kalathiya²* (1. University of Edinburgh, United Kingdom; 2. University of Gdansk, Poland)
22. 从生物活性化合物库中发现乙型肝炎病毒亚病毒颗粒生物生成抑制剂
Discovery of hepatitis B virus subviral particle biogenesis inhibitors from a bioactive compound library
Biplav Shrestha, Sisi Yang, Ju-Tao Guo* (Baruch S. Blumberg Institute, USA)
23. KDM5A/B有助于HIV-1潜伏感染和HIV-1感染细胞的存活
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells
Tai-Wei Li, Youngmin Park, Jian Zhu* (The Ohio State University, USA)
24. 利用SARS-CoV-2入侵宿主增强子作为新型抗病毒治疗的靶标
Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy
Nathalia Williams, Mirco Schmolke* (University of Geneva, Switzerland)
25. 表征对HIV-1抑制剂temsavir和ibalizumab不敏感的临床包膜

Characterization of clinical envelopes with lack of sensitivity to the HIV-1 inhibitors temsavir and ibalizumab
Margaret Gartland, Mark Krystal* (ViiV Healthcare, USA)

九、英国药理学杂志 (2024年第181卷第15-16期)

（一）August 2024 - Volume 181 - Issue 15 (2024年8月第181卷第15期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/15

Research Articles （研究文章）
1. AMPK激活通过调节皮肤中IκBζ表达来调节IL-36诱导的炎症反应
AMPK activation modulates IL-36-induced inflammatory responses by regulating IκBζ expression in the skin
Yi-Ting Huang,  Nan-Lin Wu* (MacKay Memorial Hospital, Taiwan, China; MacKay Medical College, Taiwan)
2. 鉴定一种海洋衍生的倍半萜类化合物，Compound-8，它通过阻断复合体II组装抑制肿瘤坏死因子诱导的细胞死亡
Identification of a marine-derived sesquiterpenoid, Compound-8, that inhibits tumour necrosis factor-induced cell death by blocking complex II assembly
Yuan He, Zhenyu Cai* (Shanghai Tenth People's Hospital, Tongji University School of Medicine, China)
3. P2X7受体依赖的神经细胞内源性大麻素2-花生四烯酸甘油酯产生的增加：动态和机制
P2X7 receptor-dependent increase in endocannabinoid 2-arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism
Simar Singh, Nephi Stella* (University of Washington, USA)
4. 降钙素基因相关肽诱导的人冠状动脉舒张的细胞内途径：Gβγ亚基而非cAMP的关键作用
Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP
Tessa de Vries, Antoinette MaassenVanDenBrink* (Erasmus MC University Medical Center, The Netherlands)
5. 胰岛素样生长因子结合蛋白-微纤维蛋白相关蛋白-甾体调节元件结合蛋白轴调节成纤维细胞-肌成纤维细胞转换和心脏纤维化
The insulin-like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis
Qianwen Zhao, Wenxuan Hong* (Nanjing University, China; Zhongshan Hospital Affiliated with Fudan University, China)
6. LncRNA XIST在烟草特异性肺癌致癌物NNK诱导的肺损伤中调节miR-328-3p的异位表达，无论是体外还是体内
LncRNA XIST modulates miR-328-3p ectopic expression in lung injury induced by tobacco-specific lung carcinogen NNK both in vitro and in vivo
Bingxin Li,  Ning Li* (Shenyang Pharmaceutical University, China)
7. BRD2特异性抑制剂BBC0403抑制诱导C57BL/6雄性小鼠骨关节炎病理进展
BRD2-specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis-induced C57BL/6 male mice
Hyemi Lee, Siyoung Yang* (Sungkyunkwan University, South Korea)
8. 甲基巴多索酮通过抑制巨噬细胞浸润预防与代谢功能障碍相关的脂肪性肝炎
Bardoxolone methyl prevents metabolic dysfunction-associated steatohepatitis by inhibiting macrophage infiltration
Kazuhiro Onuma, Yoichi Mizukami* (Yamaguchi University Science Research Center, Japan)
9. 新型再摄取抑制剂IP2015通过增加中枢多巴胺和外周一氧化氮释放诱导勃起
A novel reuptake inhibitor, IP2015, induces erection by increasing central dopamine and peripheral nitric oxide release
Simon Comerma-Steffensen, Ulf Simonsen* (Aarhus University, Denmark)
10. 一种天然的二萜类去饱和酶抑制剂减轻耐甲氧西林金黄色葡萄球菌(MRSA)的致病性并克服药物抗性
A natural inhibitor of diapophytoene desaturase attenuates methicillin-resistant Staphylococcus aureus (MRSA) pathogenicity and overcomes drug-resistance
Baoqing Han, Xiaodi Niu* (Jilin University, China)
11. G蛋白或阻遏蛋白亚型介导的信号传导的差异贡献是尿皮质素3诱导胰腺δ细胞生长抑素分泌的基础
Differential contributions of G protein- or arrestin subtype-mediated signalling underlie urocortin 3-induced somatostatin secretion in pancreatic δ cells
Kai-Yu Wang, Xiao Yu* (Shandong University, China)
12. 蛋白激酶A和A激酶锚定蛋白在人呼吸道平滑肌细胞中的cAMP信号传导的缓冲和区域化中的作用
Role of protein kinase A and A kinase anchoring proteins in buffering and compartmentation of cAMP signalling in human airway smooth muscle cells
Rinzhin T. Sherpa, Robert D. Harvey* (University of Nevada, Reno School of Medicine, USA)
13. 瑞德西韦和利巴韦林的协同作用导致细胞培养中SARS-CoV-2的灭绝
Synergism between remdesivir and ribavirin leads to SARS-CoV-2 extinction in cell culture
Carlos García-Crespo, Celia Perales* (Centro de Biología Molecular Severo Ochoa (CBM), CSIC-UAM, Spain; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Spain)
14. PACAP和VIP受体在脊髓中的药理学强调了PAC1受体的重要性
Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC1 receptor
Zoe Tasma, Christopher S. Walker* (The University of Auckland, New Zealand)
15. 钙感应受体通过Gi/o蛋白信号传导调节Kv7通道，并调节人诱导多能干细胞衍生的感觉神经元样兴奋性
Calcium-sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons
Nontawat Chuinsiri, Vsevolod Telezhkin* (Newcastle University, UK)

（二）August 2024 - Volume 181 - Issue 16 (2024年8月第181卷第16期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/16

1. N-甲基-D-天冬氨酸受体的产后低功能改变穿通路径突触可塑性和过滤，并损害齿状回介导的空间辨别
Postnatal hypofunction of N-methyl-D-aspartate receptors alters perforant path synaptic plasticity and filtering and impairs dentate gyrus-mediated spatial discrimination
Luis A. Márquez, Emilio J. Galván* (CINVESTAV Unidad Sur, Mexico)
2. 胰蛋白酶活性通过蛋白酶激活受体依赖机制向肠道上皮发出信号
Chymotrypsin activity signals to intestinal epithelium by protease-activated receptor-dependent mechanisms
Simon Guignard,  Nathalie Vergnolle* (Université Toulouse III—Paul Sabatier (UPS), France)
3. 羟甲基戊二酰辅酶A还原酶活性对脂肪酸的线粒体β-氧化至关重要，以防止长链酰基肉碱在小鼠肝脏中致命积累
Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver
Edgars Liepinsh* (Latvian Institute of Organic Synthesis, Latvia)
4. 白色脂肪组织，一个新的抗风湿靶点：其分泌能力及脂肪切除基础治疗的线索
White adipose tissue, a novel antirheumatic target: Clues from its secretory capability and adipectomy-based therapy
Peng Ye, Jian Zuo* (The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), China)
5. 瞬时受体电位踝蛋白1通道通过与多巴胺转运体的相互作用调节甲基苯丙胺的滥用相关机制
Transient receptor potential ankyrin 1 channel modulates the abuse-related mechanisms of methamphetamine through interaction with dopamine transporter
Kwang-Hyun Hur, Choon-Gon Jang* (Sungkyunkwan University, Republic of Korea)
6. 信号开关维持血管内皮细胞间的通信
Signalling switches maintain intercellular communication in the vascular endothelium
Charlotte Buckley, John G. McCarron* (University of Strathclyde, UK)
7. 早期红细胞铁调素水平可以预测对促红细胞生成素的长期血红蛋白反应
Early erythroferrone levels can predict the long-term haemoglobin responses to erythropoiesis-stimulating agents
Peng Xu, Xiaoyu Yan* (The Chinese University of Hong Kong, China)
8. 三个半胱氨酸基序作为主要决定因素，调节对乙酰氨基酚代谢产物N-乙酰-p-苯醌亚胺对神经元KV7通道的调节
A triple cysteine motif as major determinant of the modulation of neuronal KV7 channels by the paracetamol metabolite N-acetyl-p-benzo quinone imine
Sutirtha Ray, Isabella Salzer* (Medical University of Vienna, Austria)
9. 催产素拮抗剂Cligosiban减少人前列腺收缩性：对良性前列腺增生治疗的启示
The oxytocin antagonist cligosiban reduces human prostate contractility: Implications for the treatment of benign prostatic hyperplasia
Beatrix Bester* (Justus-Liebig-University, Germany)
10. 载锌原卟啉纳米粒子改善肥胖期间的葡萄糖稳态和慢性炎症
ZnPP-laden nanoparticles improve glucose homeostasis and chronic inflammation during obesity
Wanbao Yang, Shaodong Guo* (Texas A&M University, USA)
11. 自体激活的P2X7受体介导嗜铬细胞中的儿茶酚胺分泌
Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells
María Constanza Maldifassi* (Universidad de Valparaíso, Chile)
12. 长效FGF21通过调节NR4A1介导的Ly6C表型转换在巨噬细胞中减轻与代谢功能障碍相关的脂肪性肝炎相关纤维化
A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages
Yue Ji, Xiangdong Gao* (China Pharmaceutical University, China)
13. 大豆异黄酮改善斑马鱼模型中锰诱导的帕金森病的非运动症状：行为和生化方法
Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach
Balasubramanian Haridevamuthu, Jesu Arockiaraj* (Saveetha Institute of Medical and Technical Sciences (SIMATS), India)
14. 卡非佐米诱导的心脏毒性中心血管代谢综合征和心力衰竭早期阶段的含义和隐藏毒性
Implications and hidden toxicity of cardiometabolic syndrome and early-stage heart failure in carfilzomib-induced cardiotoxicity
Panagiotis Efentakis* (National and Kapodistrian University of Athens, Greece)
15. 针对IL-11以减少肺动脉高压相关肺纤维化动物模型中的纤维细胞循环和肺部积累
Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis
Javier Milara* (Health Institute Carlos III, Spain)

十、临床药代动力学 (2024年第63卷第8期)

August 2024 -Volume 63 - Issue 8 (2024年8月第63卷第8期)
https://link.springer.com/journal/40262/volumes-and-issues/63-8

Systematic Review（系统综述）
1. 我们能否预测药物排泄到唾液中？对物理化学性质的系统综述和分析
Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties
Thi A. Nguyen* (The University of Sydney, Australia)
2. 创新硫唑嘌呤治疗药物监测：DNA-硫鸟嘌呤核苷（DNA-TG）作为硫唑嘌呤治疗中包容性生物标志物的系统综述和Meta分析
Innovating Thiopurine Therapeutic Drug Monitoring: A Systematic Review and Meta-Analysis on DNA-Thioguanine Nucleotides (DNA-TG) as an Inclusive Biomarker in Thiopurine Therapy
Ahmed B. Bayoumy* (Amsterdam University Medical Centers, Location Academic Medical Center, The Netherlands)
Original Research Article（原创研究文章）
3. 在血浆蛋白结合改变的情况下，最需要对分布容积低于1.3 L/kg的药物进行剂量调整
Dosing Adjustments in Cases of Altered Plasma Protein Binding are Most Needed for Drugs with a Volume of Distribution Below 1.3 L/kg
Florin M. Musteata* (Albany College of Pharmacy and Health Sciences, USA)
4. 肝脏和首过CYP3A活性的静脉和口服探针在个体内变异性
Intrasubject Variability in Intravenous and Oral Probes for Hepatic and First-Pass CYP3A Activity
Evan D. Kharasch* (Duke University School of Medicine, USA)
5. 预测达托霉素起始剂量的机器学习算法
A Machine Learning Algorithm to Predict the Starting Dose of Daptomycin
Florence Rivals, Jean-Baptiste Woillard* (Toxicologie et Pharmacovigilance, France)
6. 基于临床试验数据的药物-药物相互作用风险评估：快速准确的决策工具
Clinical Trial Data-Driven Risk Assessment of Drug–Drug Interactions: A Rapid and Accurate Decision-Making Tool
Tong Yuan, Jin Yang* (China Pharmaceutical University, China)
7. 脓毒症休克患者连续性肾脏替代治疗期间的抗生素清除：混合模式与“扩展血液透析”
Antibiotics Removal during Continuous Renal Replacement Therapy in Septic Shock Patients: Mixed Modality Versus “Expanded Haemodialysis”
Fiorenza Ferrari, Christian Zanza* (San Bortolo Hospital, Italy; University of Rome “Tor Vergata”, Italy)
8. 基于生理的药代动力学模型和非线性混合效应方法对OATP1B底物的研究：估算经验体外到体内比例因子
Physiologically Based Pharmacokinetic Model of OATP1B Substrates with a Nonlinear Mixed Effect Approach: Estimating Empirical In Vitro-to-In Vivo Scaling Factors
Rui Li* ( Pfizer Global Research and Development, USA)
9. 晚期或转移性实体瘤患者卡皮瓦塞替的群体药代动力学
Population Pharmacokinetics of Capivasertib in Patients with Advanced or Metastatic Solid Tumours
Carlos Fernandez-Teruel, Marie Cullberg* (BioPharmaceuticals R&D, UK; BioPharmaceuticals R&D, Sweden)
10. 心脏手术及体外循环前后新生儿危重先天性心脏病患者别嘌醇和氧嘌醇的群体药代动力学和目标达成
Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease
Wan-Yu Chu¹, Maaike Nijman², Alwin D. R. Huitema¹* (1. The Netherlands Cancer Institute, The Netherlands; 2. University Medical Center (UMC) Utrecht, Utrecht University, The Netherlands)