一、临床药理学与治疗学 (2024年第115卷第5期)

May 2024 - Volume 115 - Issue 5 (2024年5月第115卷第5期)
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2024/115/5

White Papers（白皮书）
1. 非标记、稳定同位素标记和放射性标记方法在人体静脉药代动力学数据提供中的比较：讨论文稿
Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece
作者：Graeme C. Young* (GSK Research &Development Ltd., UK)
2. 药物开发中的代谢物生物分析：国际药品开发创新与质量联盟代谢物生物分析工作组的建议
Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group
作者：Wenkui Li*, Faye Vazvaei-Smith* (Novartis Biomedical Research, USA; Merck & Co., Inc., USA)

Reviews（综述）
1. 中国专家共识：他汀类药物不耐受的临床诊断与管理
Chinese Expert Consensus on the Clinical Diagnosis and Management of Statin Intolerance
作者：Jian-Jun Li*, Ke-Fei Dou* (Fu Wai Hospital, China)

Mini Review（微综述）
1. 公共研讨会总结报告：结合ICH E17指南概念的多区域临床试验案例研究
Summary Report of a Public Workshop: Case Studies of Multi-Regional Clinical Trial Incorporating Concept of the ICH E17 Guideline
作者：Nobuko Matsushima* (Clinical Pharmacology & Pharmacometrics, Global R&D, Janssen Pharmaceutical K.K., Japan)

Systematic Review（系统综述）
1. 改善获得性脑损伤后认知功能的药物治疗：一项Meta分析和Meta回归研究
Pharmacotherapy to Improve Cognitive Functioning After Acquired Brain Injury: A Meta-Analysis and Meta-Regression
作者：Ruud van der Veen*  (Emma Children's Hospital, The Netherlands)

Research（研究）
1. 制药和医疗器械公司在临床试验中对数字健康技术应用的缓慢接受
Tepid Uptake of Digital Health Technologies in Clinical Trials by Pharmaceutical and Medical Device Firms
作者：Caroline Marra, Ariel D. Stern* (Harvard University, USA; Harvard Business School & Harvard-MIT Center for Regulatory Science, USA)

Articles（文章）
1. 基于计算机模拟背景消除的循环肿瘤DNA分析方法指导鼻咽癌的化疗
Circulating Tumor DNA Profiling Approach Based on In Silico Background Elimination Guides Chemotherapy in Nasopharyngeal Carcinoma
作者：Ming Li, Lvyun Zhu* (College of Sciences, National University of Defense Technology, China)
2. 基于模型的Meta分析：美国风湿病学会反应标准下Bimekizumab在银屑病关节炎中的比较有效性
Comparative Effectiveness of Bimekizumab in Psoriatic Arthritis: A Model-Based Meta-Analysis of American College of Rheumatology Response Criteria
作者：Alan Maloney, Ghada F. Ahmed* (UCB Pharma, UK)
3. 将血浆脂蛋白结合纳入生理药动学模型的意义：以胺碘酮为对象的模拟研究
Implications of Incorporating Plasma Lipoprotein Binding into a Physiologically-Based Pharmacokinetic Model: A Simulation Study with Amiodarone
作者：Kosuke Doki* (University of Tsukuba, Japan)
4. 卡马西平的CYP3A4诱导潜力评估：来自两项临床DDI研究和PBPK建模的洞见
Assessment of the CYP3A4 Induction Potential by Carbamazepine: Insights from Two Clinical DDI Studies and PBPK Modeling
作者：Friederike Kanefendt, Marcus-Hillert Schultze-Mosgau* (Clinical Pharmacology, Bayer AG, Germany)
5. 注意力缺陷/多动障碍儿童和青少年中阿托莫西汀及其代谢物的群体药代动力学分析
Population Pharmacokinetic Analysis of Atomoxetine and its Metabolites in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
作者：Shen Cheng, Jacob T. Brown* (University of Minnesota, USA; University of Minnesota College of Pharmacy, USA)
6. 使用外排比率-相对表达因子方法(ER-REF)和PBPK模型与模拟成功预测双重BCRP/P-gp药物底物的胎儿暴露量
Successful Prediction of Fetal Exposure to Dual BCRP/P-gp Drug Substrates Using the Efflux Ratio-Relative Expression Factor Approach and PBPK M&S
作者：Ankit Balhara, Jashvant D. Unadkat* (University of Washington, USA)
7. 使用基于机制的生理药代动力学-药效学模型预测siRNA治疗药物的临床药代动力学/药效学及器官损伤对其的影响
Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA-Based Therapeutics Using a Mechanistic Physiologically-Based Pharmacokinetic-Pharmacodynamic Model
作者：Annie Lumen, Vijay V. Upreti * (Clinical Pharmacology, Modeling, and Simulation, Amgen Inc., USA)
8. CYP2D6表型影响文拉法辛的药代动力学参数：来自老年抑郁症患者群体药代动力学模型的结果
CYP2D6 Phenotype Influences Pharmacokinetic Parameters of Venlafaxine: Results from a Population Pharmacokinetic Model in Older Adults with Depression
作者：Xiaoyu Men, Daniel J. Müller* (University of Toronto, Canada)
9. I期、随机、多剂量研究：评估JAK抑制剂Lorpucitinib在健康参与者中的肠道选择性和安全性
A Phase I, Randomized, Multi-Dose Study to Evaluate the Enteric Selectivity and Safety of JAK Inhibitor, Lorpucitinib, in Healthy Participants
作者：Xuewen Ma, Edward Attiyeh* (Janssen Research & Development, LLC, USA)
10. 生物粘附性屏障形成凝胶（Episil）改善乳腺癌患者的急性放射性皮炎：一项单中心、开放、平行、随机、I/II期对照试验
Amelioration of Acute Radiation Dermatitis in Breast Cancer Patients by a Bioadhesive Barrier-Forming Gel (Episil): A Single-Center, Open, Parallel, Randomized, Phase I/II Controlled Trial
作者：Qian Li1, Fangling Ning2*, Judong Luo3*, Changmin Liu2* (1. Binzhou Medical University, China; 2. Binzhou Medical University Hospital, China; 3. Tongji Hospital of Tongji University School of Medicine, China)
11. 基于模型的效益/风险分析：Copanlisib间歇剂量方案
Model-Based Benefit/Risk Analysis for the Copanlisib Intermittent Dosing Regimen
作者：Peter N. Morcos* (Bayer HealthCare Pharmaceuticals, Inc., USA)
12. 非洲感染HIV儿童口服洛匹那韦/利托那韦颗粒剂的群体药代动力学
Population Pharmacokinetics of Pediatric Lopinavir/Ritonavir Oral Pellets in Children Living with HIV in Africa
作者：Suthunya Chupradit, Tim R. Cressey*, Baralee Punyawudho* (Chiang Mai University, Thailand)
13. 基于定量模型的单一及联合镰状细胞病治疗策略评估
Quantitative Model-Based Assessment of Multiple Sickle Cell Disease Therapeutic Approaches Alone and in Combination
作者：Amy T. Moody* (Pfizer Inc., USA)
14. 一项回顾性分析：聚集体差异对生物类似药及其参考产品的临床免疫原性潜在影响
A Retrospective Analysis of the Potential Impact of Differences in Aggregates on Clinical Immunogenicity of Biosimilars and their Reference Products
作者：Cristina Fernandez-Mendivil, Hans C. Ebbers* (Biogen International GmbH, Switzerland)
15. 钠-葡萄糖共转运体2抑制剂与治疗膀胱过度活跃药物的联合使用与尿路感染风险
Concomitant Use of Sodium-Glucose Cotransporter 2 Inhibitors and Overactive Bladder Drugs and the Risk of Urinary Tract Infection
作者：Sungho Bea, Ju-Young Shin* (Sungkyunkwan University, South Korea)
16. 质子泵抑制剂诱导的肾损伤与CYP2C19多态性的关联：一项回顾性队列研究
Relationships of Proton Pump Inhibitor-Induced Renal Injury with CYP2C19 Polymorphism: A Retrospective Cohort Study
作者：Rika Fukui, Satoshi Noda*, Shin-ya Morita* (Shiga University of Medical Science, Japan)
17. IL-17A口服小分子抑制剂（LY3509754）的安全性、耐受性和药代动力学：一项I期随机安慰剂对照研究
Safety, Tolerability, and Pharmacokinetics of an Oral Small Molecule Inhibitor of IL-17A (LY3509754): A Phase I Randomized Placebo-Controlled Study
作者：Amita Datta-Mannan* （Eli Lilly and Company, USA）
18. 基于模型的癌症患者伊立替康诱导的4级中性粒细胞减少症预测：将生殖系遗传因素纳入模型的影响
Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Cancer Patients: Influence of Incorporating Germline Genetic Factors in the Model
作者：Spinel Karas, Robert R. Bies* (University of North Carolina at Chapel Hill, USA; State University of New York at Buffalo, USA)

二、药理学评论

May 2024 - Volume 76 - Issue 3 (2024年5月第76卷第3期)
https://pharmrev.aspetjournals.org/content/76/3

Review Articles（综述文章）
1. 锂的药理学和毒理学新进展：神经生物学导向的综述
New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
作者：Analia Bortolozzi, Andre F. Carvalho* (Spanish National Research Council (CSIC), Spain; Deakin University, Australia)
2. 肾上腺素受体脱敏：对机制的当前理解
Adrenoceptor Desensitization: Current Understanding of Mechanisms
作者：Dina Maaliki, Ali H. Eid* (American University of Beirut, Lebanon)
3. 前列腺素E2在肿瘤微环境中的作用：由EP受体2和4介导的复杂事件
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
作者：Ana Santiso, Julia Kargl (Medical University of Graz, Austria)
4. MDM2抑制剂在癌症治疗中的应用：过去、现在和未来
MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
作者：Wei Wang,  Ruiwen Zhang* (University of Houston, USA)
5. 脂肪性肝病：病理生理学和新兴药物治疗
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies
作者：Michail Kokkorakis, Christos S. Mantzoros* (Harvard Medical School, USA)
6. 控制肝脏再生终止的分子途径
Molecular Pathways Governing the Termination of Liver Regeneration
作者：Lianne R. de Haan, Michal Heger* (Jiaxing University, China)

三、先进药物输送评论 (2024年第208卷)

May 2024 - Volume 208 (2024年5月第208卷)
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/208/suppl/C

Review article（综述文章）
1. 用于超声波调节的中枢和外周神经系统药物输送的微型化治疗系统
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system
作者：Pancheng Zhu¹, Ignasi Simon¹, Daniel S. Kohane²*, Alina Y. Rwei¹* (1. Delft University of Technology, the Netherlands; 2. Boston Children’s Hospital, Harvard Medical School, USA)
2. 非病毒RNA传递用于治疗性T细胞工程
Non-viral delivery of RNA for therapeutic T cell engineering
作者：Dominika Berdecka, Kevin Braeckmans* (Ghent University, Belgium)
3. 生物工程工具箱：增强类器官治疗的潜力
Bioengineering toolkits for potentiating organoid therapeutics
作者：Sewon Park, Seung-Woo Cho* (Yonsei University, Republic of Korea)
4. 将超声波介导的药物输送技术应用于中枢神经系统
Translating ultrasound-mediated drug delivery technologies for CNS applications
作者：Ederlyn Perolina, Darren Svirskis* (University of Auckland, New Zealand)
5. 高级三维成像与类器官生物打印在生物医学研究和治疗应用
Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications
作者：Sushila Maharjan¹, Junjie Yao²*, Yu Shrike Zhang¹* (1. Brigham and Women’s Hospital, USA; 2. Duke University, USA)
6. RNA疗法在治疗中枢神经系统（CNS）疾病中的研究
RNA therapies for CNS diseases
作者：Valentina Di Francesco, Mansoor M. Amiji* (Northeastern University, USA)
7. 脂质纳米颗粒用于RNA传递：自组装与驱动组装策略
Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies
作者：Valeria Nele, Giuseppe De Rosa* (University of Naples Federico II, Italy)
8. 弥合测试与临床之间的差距：探索黑色素瘤研究中的替代性前临床模型
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
作者：Juliana Viegas, Bruno Sarmento* (Universidade do Porto, Portugal)
9. 临床视角下的局部疫苗接种策略
Clinical perspective on topical vaccination strategies
作者：Petya G. Popova, Sunny P. Chen, Anna K. Blakney* (University of British Columbia, Canada)
10. 罕见皮肤疾病基因编辑中的挑战与进展
Challenges and progress related to gene editing in rare skin diseases
作者：Josefina Piñón Hofbauer, Ulrich Koller* (University Hospital of the Paracelsus Medical University, Austria)
11. 基于水凝胶载体的类风湿性关节炎治疗递送系统
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
作者：Fabiola A. Chapa-Villarreal, Nicholas A. Peppas* (The University of Texas at Austin, USA)
12. 心血管疾病治疗中RNA递送系统的探索
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
作者：Paula Gil-Cabrerizo, Elisa Garbayo*, María J. Blanco-Prieto* (University of Navarra, Spain)

四、药理学发展趋势 (2024年第45卷第5期)

May 2024 - Volume 45 - Issue 5 (2024年5月第45卷第5期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(23)X0006-6#closeFullCover

Spotlight（聚焦）
1. VMAT结构揭示了药物开发中的激动人心的目标
VMAT structures reveal exciting targets for drug development
作者：Shimon Schuldiner*, Lucy R. Forrest* (Hebrew University of Jerusalem, Israel; National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA)
2. 创伤性脑损伤引起的脑水肿导致淋巴液停滞型脑水肿
Glymphatic-stagnated edema induced by traumatic brain injury
作者：Per Kristian Eide* (Oslo University Hospital – Rikshospitalet, Norway)

Forum（论坛）
1. 电疗法：神经系统和可兴奋组织之外的新兴应用
Electroceuticals: emerging applications beyond the nervous system and excitable tissues
作者：Swarnalatha Balasubramanian, Devon Charles Cardoso Davidian* (BioPharmaceuticals R&D, USA; Tufts University, USA)

Reviews（综述）
1. 靶向癌症中的甲硫氨酸代谢：机遇与挑战
Targeting methionine metabolism in cancer: opportunities and challenges
作者：Peng Bin, Wenkai Ren* (South China Agricultural University, China)
2. 体内直接工程化CAR T细胞
Direct in vivo CAR T cell engineering
作者：Lauralie Short¹, Pieter R. Cullis²*, Laura Evgin¹* (1. BC Cancer Research Institute, Canada; 2. University of British Columbia, Canada)
3. Frizzleds作为动态的药物作用实体
Frizzleds act as dynamic pharmacological entities
作者：Gunnar Schulte* (Karolinska Institutet, Sweden)
4. AML治疗：传统化疗与新兴新型药物
AML treatment: conventional chemotherapy and emerging novel agents
作者：Mark Forsberg, Marina Konopleva* (Montefiore Einstein Cancer Center, USA)
5. 异双功能小分子调节RNA功能
Heterobifunctional small molecules to modulate RNA function
作者：Sandra Kovachka, Matthew D. Disney* (The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, USA)

五、药理学与治疗学 (2024年第257卷)

May 2024 - Volume 254 (2024年5月第257卷)
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/257/suppl/C

Review article（综述文章）
1. 临床前癌症研究中的原位和转移性肿瘤模型
Orthotopic and metastatic tumour models in preclinical cancer research
作者：Stephen M. Stribbling*, Anderson J. Ryan* (University College London, UK; University of Oxford, UK)
2. 抑郁症的免疫疗法：最新见解与未来靶点
Immunotherapy for depression: Recent insights and future targets
作者：Ying Bai* (Southeast University, China)
3. 经动脉化疗栓塞 (TACE) 联合仑伐替尼和PD-1抑制剂在治疗晚期肝细胞癌中的疗效与安全性：一项Meta分析
Efficacy and safety of transarterial chemoembolization combined with lenvatinib and PD-1 inhibitor in the treatment of advanced hepatocellular carcinoma: A meta-analysis
作者：Lei Wang, Wei Zhou* (The First Affiliated Hospital of China Medical University, China)
4. 慢性阻塞性肺疾病及其并发症中的肌肉骨骼串扰：新兴作用与治疗潜力
Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials
作者：Kevin Mou, Ross Vlahos* (RMIT University, Australia)
5. CBP/p300抑制剂的抗癌活性特征 - 它们类别的特性、细胞内靶标及在癌症治疗中应用的未来展望
Characteristics of anticancer activity of CBP/p300 inhibitors – Features of their classes, intracellular targets and future perspectives of their application in cancer treatment
作者：Magdalena Strachowska, Agnieszka Robaszkiewicz* (University of Lodz,  Poland)
6. 表观遗传决定因素与促进心脏生长和再生的非心肌信号通路
Epigenetic determinants and non-myocardial signaling pathways contributing to heart growth and regeneration
作者：Jihyun Jang*, Deqiang Li* (Nationwide Children's Hospital, USA)
7. SIRT3：治疗肝纤维化的潜在靶点
SIRT3: A potential therapeutic target for liver fibrosis
作者：Yan Ning, Xinyue Dou, Xin Han*, Gang Cao* (Zhejiang Chinese Medical University, China)

六、药物 (2024年第84卷第5期)

May 2024 - Volume 84 - Issue 5 (2024年5月第84卷第5期)

5月没更新

七、药理学研究 (2024年第203卷)

May 2024 - Volume 203 (2024年5月第203卷)
https://www.sciencedirect.com/journal/pharmacological-research/vol/203/suppl/C

Review Articles（综述文章）
1. 红细胞生成素作为慢性肾病相关认知功能障碍的神经保护剂的有效性：文献系统综述
Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review
作者：Michelangela Barbieri* (University of Campania "Luigi Vanvitelli", Italy)
2. 血管周围脂肪组织与血管老化：促进与保护的双重作用
Perivascular fat tissue and vascular aging: A sword and a shield
作者：Yan Wang¹, Xianmin Wang², Yang Chen³, Guangjian Jiang¹* (1. Beijing University of Chinese Medicine, China; 2. Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, China; 3. Xinjiang Medical University, China)
3. 内质网-细胞器接触：神经系统疾病的信号中心
ER-organelle contacts: A signaling hub for neurological diseases
作者：Yunli Wang, Jinghua Yang* (Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), China)
4. 血清素在肾脏疾病中的线粒体调节
Serotonin regulation of mitochondria in kidney diseases
作者：Kevin Hurtado, Rick G. Schnellmann* (University of Arizona, USA)
5. SIRT1：利用多条途径来阻止非酒精性脂肪肝疾病的发展
SIRT1: Harnessing multiple pathways to hinder NAFLD
作者：Cheng Tian, Ming Xiang* ( Huazhong University of Science and Technology, China)
6. 免疫刺激抗体偶联物 (ISACs) 何时能从实验室走向临床应用？
When will the immune-stimulating antibody conjugates (ISACs) be transferred from bench to bedside?
作者：Chen Fu¹, Weiwei Tong², Bo Chen³*, Minjie Wei¹* (1. China Medical University, China; 2. Shengjing Hospital of China Medical University, China; 3. The First Hospital of China Medical University, China)
7. 自噬与铁死亡之间的相互作用为神经内分泌前列腺癌提供了一种新颖的治疗概念框架
The interplay between autophagy and ferroptosis presents a novel conceptual therapeutic framework for neuroendocrine prostate cancer
作者：Youzhi Wang¹, Ning Wu², Junbo Li¹, Jiaming Liang¹, Diansheng Zhou¹, Xuesong Li³*, Ning Jiang¹* (1. The Second Hospital of Tianjin Medical University, China; 2. Peking University Third Hospital, China; 3. Peking University First Hospital, China)
8. 肝细胞癌中T细胞耗竭的分子机制解析
Molecular insight into T cell exhaustion in hepatocellular carcinoma
作者：Yonghua Zhu¹, Huabing Tan², Jincheng Wang³, Huanbin Zhao⁴*, Xiaojie Lu¹* (1. The First Affiliated Hospital of Nanjing Medical University, China; 2. Renmin Hospital, Hubei University of Medicine, China; 3. Hokkaido University, Japan; 4. St. Jude Children’s Research Hospital, USA)
9. 封装细胞技术：传递细胞因子以治疗眼后段疾病
Encapsulated cell technology: Delivering cytokines to treat posterior ocular diseases
作者：Jiale Wang, Zongming Song*, Ye Tao* (Henan Provincial People’s Hospital, China)
10. 心血管疾病中的Mitofilin：对发病机制的洞见及潜在的药物干预
Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions
作者：Abdallah Iddy Chaurembo¹, Na Xing¹*, Han-bin Lin¹*, Kai-xuan Lin²* (1. Chinese Academy of Sciences, China; 2. Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, China)
11. 主要组织相容性复合体在帕金森病中的作用
The major histocompatibility complex participates in Parkinson’s disease
作者：Rou Gu, Jie Bai* (Kunming University of Science and Technology, China)
12. 5-羟色胺功能障碍可能介导饮酒与阿尔茨海默病之间的关系
Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer’s disease
作者：Samantha R. Pierson, Catherine A. Marcinkiewcz* (University of Iowa, USA)
13. 免疫治疗的新时代：CAR-T细胞为基础药物的最新进展和未来考量
The new era of immunological treatment, last updated and future consideration of CAR T cell-based drugs
作者：Kaveh Hadiloo, Abdolreza Esmaeilzadeh* (Zanjan University of Medical Sciences, Iran)
14. 针对癌症中药物耐受性持久者细胞的药理学药物
Pharmacological agents targeting drug-tolerant persister cells in cancer
作者：Yu-Chi Chen, Gavin P. Robertson* (The Pennsylvania State University College of Medicine, USA)
15. 基于顺铂的联合疗法：重点关注人参皂苷的共同给药及其疗效
Cisplatin-based combination therapies: Their efficacy with a focus on ginsenosides co-administration
作者：Keke Li, Jiwen Li, Xiaojie Gong* (Ministry of Education, China)
16. 硫化氢补充作为原发性线粒体病的潜在治疗方法
Hydrogen sulfide supplementation as a potential treatment for primary mitochondrial diseases
作者：Luke Slade, Timothy Etheridge, Matthew Whiteman* (University of Exeter, UK)
17. 揭示肿瘤内微生物群：结直肠癌诊断和治疗的新兴力量
Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy
作者：Jinjing Zhang, Penghui Wang, Xiaojie Wei*, Mengchuan Wang* (Wenzhou Medical University, China)
18. 通过调节外泌体蛋白质装载和功能治疗癌症：天然产物和中药的前景
Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine
作者：Lulu Meng, Chao Zhang*, Pei Yu* (Key Laboratory of Natural Medicines, China)
19. 免疫检查点抑制剂与靶向蛋白激酶抑制剂联合治疗肾细胞癌
Combination immune checkpoint and targeted protein kinase inhibitors for the treatment of renal cell carcinomas
作者：Robert Roskoski Jr.* (Blue Ridge Institute for Medical Research, USA)
20. 炎症性肠病中Th17/Treg平衡的代谢调节
Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease
作者：Shunfen Zhang, Ruqing Zhong, Liang Chen*, Hongfu Zhang* (Chinese Academy of Agricultural Sciences, China)
21. 针对调节细胞焦亡的表观遗传和翻译后修饰治疗炎症性疾病
Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases
作者：Ri-Wen, Yu-Hang Yang, Chun-Feng Liu*, Ni Yang* (Shengjing Hospital of China Medical University, China)
22. IUPHAR ECR综述：癌症患者的癌性厌食恶病质：病理生理学和治疗
IUPHAR ECR review: Cancer-related anorexia-cachexia in cancer patients: Pathophysiology and treatment
作者：Iftekhar Hossain Chowdhury* (Mugda Medical College, Bangladesh)

Research article（研究文章）
1. 基于天然产物的无载体非共价纳米颗粒在肿瘤化学光动力联合治疗中的应用
Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy
作者：Zhonglei Wang, Liyan Yang* (Universities of Shandong Province, China; Qufu Normal University, China)
2. 传统中医药与肠道微生物群在癌症中的相互作用：现状与未来展望
The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives
作者：Xuejiao Wei, Zhongdong Hu* (Beijing University of Chinese Medicine, China)
3. 内皮腺苷受体2A的阻断通过抑制CREB-ALK5介导的内皮向间质转化在体内抑制动脉粥样硬化
Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition
作者：Yongfeng Cai¹, Yaqi Zhou², Qiuhua Yang¹, Mei Hong²*, Zhiping Liu³*, Yuqing Huo¹*
4. ADAM17抑制剂ZLDI-8通过Notch1-整合素β信号通路使肝细胞癌细胞对索拉非尼敏感
The ADAM17 inhibitor ZLDI-8 sensitized hepatocellular carcinoma cells to sorafenib through Notch1-integrin β-talk
作者：Chang Xu, Yingshi Zhang*, Qingchun Zhao* (Shenyang Pharmaceutical University, China)
5. 1型糖尿病疾病改变性免疫治疗的机遇与挑战：系统综述和元分析
The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: A systematic review and meta-analysis
作者：Chu Lin, Suiyuan Hu, Xiaoling Cai*, Linong Ji* (Peking University People’s Hospital, China)
6. 治疗性固定肽：疗效与分子靶标
Therapeutic stapled peptides: Efficacy and molecular targets
作者：Yulei Li* (Shandong First Medical University & Shandong Academy of Medical Sciences, China)
7. 调节性T细胞的耗竭增强了实体肿瘤中原位疫苗的抗肿瘤效果
Depletion of regulatory T cells enhancing the anti-tumor effect of in situ vaccination in solid tumors
作者：Ya-Jia Xie, Xing-Xing Fan* (Macau University of Science and Technology, Macao, China) 
8. 来自珊瑚Zoanthus sociatus的一种新的无脊椎动物NPY样多肽ZoaNPY，作为人类NPY Y2受体的新配体，通过PLC/PKC和Src-FAK依赖的信号通路挽救血管不足
A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways
作者：Qian Chen, Guiyi Gong*, Simon Ming-Yuen Lee* (Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), China; University of Macau, Macao, China)
9. 大麻二酚对脆性X综合征活体模型中物体识别记忆的积极影响：海马GPR55受体的必要作用
Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors
作者：Antonia Manduca* (Sapienza University of Rome, Italy)
10. 靶向AQP9通过抑制LPA-hippo途径增强了克罗恩病中抗TNF疗法的响应
Targeting AQP9 enhanced the anti-TNF therapy response in Crohn's disease by inhibiting LPA-hippo pathway
作者：Minhao Yu¹, Yuan Shi¹, Yuan Gao¹, Yang Luo¹, Jun Qin¹*, Zhijun Cao²*, Ming Zhong¹* (1. Renji Hospital, China; 2. Shanghai Institute of Digestive Disease, China)
11. 心肌细胞、心脏内皮细胞和成纤维细胞通过RAS同源小GTP酶RAC1和CDC42促成了蒽环类药物引起的心脏损伤
Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42
作者：Pelin Kücük* (Heinrich Heine University Düsseldorf, Germany)
12. 特异质药物性肝损伤中的再挑战：根据现有定义对两个大型前瞻性登记处案例的分析
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions
作者：J.M. Pinazo-Bandera, H. Niu, I. Alvarez-Alvarez, R.J. Andrade* (University Hospital Virgen de la Victoria, Spain)
13. IL20Rb通过增强骨髓来源的促纤维化巨噬细胞活化加剧肺纤维化
IL20Rb aggravates pulmonary fibrosis through enhancing bone marrow derived profibrotic macrophage activation
作者：Jingyan Zhu, Cheng Yang* (Nankai University, China)
14. 表达肿瘤靶向免疫细胞因子IL-12的间皮素CAR-T细胞具有持久的疗效和较少的副作用
Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects
作者：Yuankui Zhu, Mingqian Feng* (Huazhong Agricultural University, China)
15. 靶向癌症中YAP/TAZ轴的天然化合物：现状与挑战
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges
作者：Aviral Kumar, Ajaikumar B. Kunnumakkara* (Indian Institute of Technology Guwahati (IITG), India)
16. 验证收集和厌氧发酵技术以测量益生元对肠道菌群的影响
Validation of collection and anaerobic fermentation techniques for measuring prebiotic impact on gut microbiota
作者：Alexander W. Thorman* (University of Cincinnati College of Medicine, USA)

八、抗病毒研究 (2024年第225卷)

May 2024 - Volume 225 (2024年5月第225卷)
https://www.sciencedirect.com/journal/antiviral-research/vol/225/suppl/C

Research article（研究文章）
1. 宿主靶向抗病毒药物Zapnometinib对SARS-CoV-2抗性发展展现出高障碍
The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance
作者：André Schreiber, Stephan Ludwig* (University Hospital Muenster, Germany)
2. 通过韭菜提取物和凝集素定向抑制SARS-CoV-2的糖基，并深入理解Concanavalin A的作用机制
Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A
作者：Maja Klevanski* (Heidelberg University, Germany)
3. 构建载LL-37的外泌体及其对寨卡病毒感染的防护作用
Construction of exosome-loaded LL-37 and its protection against zika virus infection
作者：Chen Wang¹, Min Li¹, Hongqi Wei²*, Lin Wei¹* (1. Soochow University, China; 2. The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, China)
4. 使用单价和多价佐剂糖蛋白疫苗对埃博拉、苏丹和本迪布焦埃博拉病毒的广泛抗体和T细胞反应
Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- and multi-valent adjuvanted glycoprotein vaccines
作者：Jiin Felgner, D. Huw Davies* (University of California Irvine, USA)
5. 咖啡酸苯乙酯：一种有效的针对猪繁殖与呼吸综合征病毒的抗病毒剂
Caffeic acid phenethyl ester: an effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus
作者：Zhanding Cui, Zengjun Lu* (Chinese Academy of Agricultural Sciences, China)
6. β-D-N4-羟基胞啶 (NHC，EIDD-1931) 抑制了在蚊细胞和离体埃及伊蚊肠道中的基孔肯雅病毒复制，但在吸血期间摄取时则无效
β-D-N4-hydroxycytidine (NHC, EIDD-1931) inhibits chikungunya virus replication in mosquito cells and ex vivo Aedes aegypti guts, but not when ingested during blood-feeding
作者：Ana Lucia Rosales-Rosas, Alina Soto, Lanjiao Wang, Leen Delang* (Laboratory of Virology and Chemotherapy, Belgium)
7. 尼马曲韦和奥米他斯韦的联合使用增强了对SARS-CoV-2复制的抑制
A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication
作者：Christopher Moon* (UK Health Security Agency, UK)
8. DDX20正向调控干扰素途径以抑制病毒感染
DDX20 positively regulates the interferon pathway to inhibit viral infection
作者：Zhiqiang Chen¹, Jinyu Zhang², Tingting Feng², Zhengrong Chen³*, Yongdong Yan³*, Jianfeng Dai²* (1. The First Affiliated Hospital of Soochow University, China; 2. Soochow University, China; 3. Children's Hospital of Soochow University, China)
9. 具有独特共价弹头的氮肽作为SARS-CoV-2主要蛋白酶抑制剂
Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors
作者：Kaustav Khatua, Yugendar R. Alugubelli, Kai S. Yang, Veerabhadra R. Vulupala, Shiqing Xu*, Wenshe Ray Liu* (Texas A&M University, USA)
10. 宿主导向的TMPRSS2抑制剂N-0385对SARS-CoV-2 Omicron亚型的纳摩尔级抗病毒活性及其与直接作用抗病毒药物的协同作用
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals
作者：Jimena Pérez-Vargas¹, Gabriel Lemieux², Richard Leduc²*, François Jean¹* (1. University of British Columbia, Canada; 2. Université de Sherbrooke, Canada)
11. 季节性疫苗补充多亚型神经氨酸酶和M2外域病毒样颗粒提高了老年小鼠对同源和异源流感病毒的保护
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
作者：Jannatul Ruhan Raha, Sang-Moo Kang* (Georgia State University, USA)
12. 基于N4-羟基胞嘧啶的新共轭物，其体外抗病毒效果比EIDD-2801对SARS-CoV-2及其他人类冠状病毒更强
New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses
作者：Andrei E. Siniavin* (Federal State Budget Institution “National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya” of the Ministry of Health of the Russian Federation, Russia)
13. 在HBV小鼠模型中，早期应用IFNγ导致HBV的持续存在
Early application of IFNγ mediated the persistence of HBV in an HBV mouse model
作者：Jingjiao Song, Xiliang Sun, Li Qin*, Dongliang Yang* (Huazhong University of Science and Technology, China)
14. 糖皮质激素受体和特异性蛋白1 (Sp1) 或Sp3，而非抗生素米特拉霉素A，刺激人类α疱疹病毒1型 (HSV-1) 复制
Glucocorticoid receptor and specificity protein 1 (Sp1) or Sp3, but not the antibiotic Mithramycin A, stimulates human alphaherpesvirus 1 (HSV-1) replication
作者：Fouad S. El-Mayet, Clinton Jones* (Oklahoma State University, USA)
15. 基于CRISPR/Cas9基因编辑技术的病毒样颗粒候选疫苗引发对SARS-CoV-2的广谱保护
A virus-like particle candidate vaccine based on CRISPR/Cas9 gene editing technology elicits broad-spectrum protection against SARS-CoV-2
作者：Weiqi Wang¹, Shen Wang², Xianyong Meng², Na Feng²*, Feihu Yan²*, Xianzhu Xia¹* (1. Jilin University, China; 2. Chinese Academy of Agricultural Sciences, China)

Review Articles（综述文章）
1. 新型递送技术在提高治疗性抗体疗效方面的进展
Progress in novel delivery technologies to improve efficacy of therapeutic antibodies
作者：Wenli Sun, Yanling Wu*, Tianlei Ying* (Fudan University, China)
2. 评估治疗性抗病毒抗体的临床前动物模型
Preclinical animal models to evaluate therapeutic antiviral antibodies
作者：Amse De Meyer, Philip Meuleman* (Ghent University, Belgium)

九、英国药理学杂志 (2024年第181卷第9-10期)

（一）May 2024 - Volume 181 - Issue 9 (2024年5月第181卷第9期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/9

Review Article（综述文章）
1. 偏倚信号转换：最后的边界？
Bias translation: The final frontier?
作者：Terry Kenakin* (University of North Carolina School of Medicine, USA)

Research Articles（研究文章）
1. 在小鼠中重复给予合成大麻素AKB48后性别特异性的行为、代谢和免疫组织化学变化
Sex-specific behavioural, metabolic, and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice
作者：Giorgia Corli¹, Elisa Roda², Liana Fattore³*, Matteo Marti¹* (1. University of Ferrara, Italy; 2. Istituti Clinici Scientifici Maugeri, Italy; 3. National Research Council, Italy)
2. 纤维细胞生长因子受体1的表达与单一药物纤维细胞生长因子受体特异性抑制剂在胰腺癌中的疗效呈负相关
Expression of fibroblast growth factor receptor 1 correlates inversely with the efficacy of single-agent fibroblast growth factor receptor-specific inhibitors in pancreatic cancer
作者：Qingxiang Lin, Robert M. Straubinger* (Roswell Park Comprehensive Cancer Center, USA)
3. 低分子量岩藻聚糖通过靶向神经氨酸酶2恢复糖尿病内皮糖萼：糖萼脱落中的新治疗靶点
Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding
作者：Zhi Li, Ning Wu*, Quanbin Zhang* (Chinese Academy of Sciences, China)
4. 静脉注射重组小脑素1治疗恢复脊髓谷氨酸δ1受体信号传导并缓解慢性疼痛
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain
作者：Siddhesh S. Sabnis, Kishore Kumar S. Narasimhan*, Shashank M. Dravid* (Creighton University, USA)
5. 前列环素受体激动剂抑制TRPM8功能需要与Gq/11蛋白偶联
Inhibition of TRPM8 function by prostacyclin receptor agonists requires coupling to Gq/11 proteins
作者：Cosmin Trif¹, Alexandru Babes²*, Sorin Tunaru¹* (1. Institute of Biochemistry of the Romanian Academy, Romania; 2. University of Bucharest, Romania)
6. 组蛋白去乙酰化酶介导的PSTPIP2表达沉默促进了马兜铃酸肾病诱导的PANoptosis
Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to aristolochic acid nephropathy-induced PANoptosis
作者：Chuanting Xu, Cheng Huang*, Taotao Ma* (Anhui Medical University, China)
7. Orexin-A通过调节下丘脑核的神经活动减轻运动病
Orexin-A attenuated motion sickness through modulating neural activity in hypothalamus nuclei
作者：Leilei Pan, Ruirui Qi*, Junqin Wang*, Yiling Cai* (Naval Medical University (Second Military Medical University), China)

（二）May 2024 - Volume 181 - Issue 10 (2024年5月第181卷第10期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/10

GPR84 Pharmacology - Themed Issue Review（GPR84药理学主题刊综述）
1. 促炎性G蛋白偶联受体GPR84的调控
Regulation of the pro-inflammatory G protein-coupled receptor GPR84
作者：Sara Marsango* (University of Glasgow, UK)
2. GPR84的偏倚激动剂及其对生物控制的洞见
Biased agonists of GPR84 and insights into biological control
作者：Vincent B. Luscombe, David R. Greaves* (University of Oxford, UK)
3. GPR84在生理学中的角色——在多种组织中的多种功能
GPR84 in physiology—Many functions in many tissues
作者：Rubina Aktar, Madusha Peiris* (Queen Mary University of London, UK)
4. 人类中性粒细胞中GPR84的功能与调控
Function and regulation of GPR84 in human neutrophils
作者：Huamei Forsman, Martina Sundqvist* (University of Gothenburg, Sweden)

十、临床药代动力学 (2024年第63卷第5期)

May 2024 -Volume 63 - Issue 5 (2024年5月第63卷第5期)
https://link.springer.com/journal/40262/volumes-and-issues/63-5

Review Article（综述文章）
1. 母乳中的药物 第1部分：在测量母乳中药物及其代谢物时的实践和分析考虑
Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk
作者：Osama Y. Alshogran, Imam H. Shaik*, Raman Venkataramanan* (University of Pittsburgh, USA)

Systematic Review（系统综述）
1. 孕期单克隆抗体的药代动力学：系统文献综述
Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
作者：J. van Gendt, Paola Mian* (University Medical Center Groningen and University of Groningen, The Netherlands)
2. 成人静脉注射利多卡因的群体药代动力学：系统综述
Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review
作者：Keng Wah Foong, Sook Hui Chaw* (Universiti Malaya, Malaysia)

Original Research Article（原创研究文章）
1. 使用基于生理的药代动力学模型预测结核性脑膜炎患者贝达喹啉中枢神经系统暴露量
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
作者：Krina Mehta* (Leiden University, The Netherlands)
2. 转移性三阴性乳腺癌及其他实体瘤患者中萨西图珠单抗的群体药代动力学
Population Pharmacokinetics of Sacituzumab Govitecan in Patients with Metastatic Triple-Negative Breast Cancer and Other Solid Tumors
作者：Abhishek G. Sathe, Ahmed A. Othman* (Clinical Pharmacology, Gilead Sciences, Inc., USA)
3. 早期肺移植后他克莫司的血药浓度变异性与临床结果：口服与持续静脉给药的比较
Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration
作者：Julia E. M. van Dommelen, Maaike A. Sikma* (University Medical Center Utrecht and Utrecht University, The Netherlands)
4. 从早产儿到青少年的米力农药代动力学中的时间变化清除率
Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
作者：Conor J. O’Hanlon, Jacqueline A. Hannam* (University of Auckland, New Zealand)
5. 使用群体药代动力学模型为软骨发育不全儿童开发Vosoritide体重分段剂量方法
Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model
作者：Yulan Qi* (BioMarin Pharmaceutical Inc., USA)
6. 健康志愿者中以儿童片剂形式给予的多替拉韦 (DTG) 和恩曲他滨/替诺福韦富马酸盐 (F/TAF) 的相对生物利用度
Relative Bioavailability of Dolutegravir (DTG) and Emtricitabine/Tenofovir Alafenamide Fumarate (F/TAF) Administered as Paediatric Tablet Formulations in Healthy Volunteers
作者：Lisanne A. H. Bevers* (Radboud University Medical Center, The Netherlands)