一、临床药理学与治疗学 (2024年第115卷第3期)

March 2024 - Volume 115 - Issue 3 (2024年3月第115卷第3期)
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2024/115/3

Editorial（社论）
1. 皮下生物制品：临床药理学与药物开发
(Subcutaneous Biologics: Clinical Pharmacology and Drug Development)
作者：Sihem Ait-Oudhia* (Merck & Co., Inc., USA)

Perspective（视角）
1. 自动注射器与预充填注射器用于皮下注射的药代动力学桥接研究：案例示例揭示知识差距
Pharmacokinetics-Bridging Between Autoinjectors and Prefilled Syringes for Subcutaneous Injection: Case Examples Revealing a Knowledge Gap
作者：Zhe Li, Yow-Ming C. Wang* (OCP, Office of Translational Sciences, CDER, FDA, USA)
2. 药物基因组学中数据共享与开放科学的当前观点
Current Perspectives on Data Sharing and Open Science in Pharmacogenomics
作者：Deanne Nixie R. Miao, Britt I. Drögemöller* (University of Manitoba, Canada)

Reviews（综述）
1. 挑战常规：多学科视角下的生物制品从静脉注射到皮下注射的桥接策略
(Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics）
作者：Sihem Ait-Oudhia, Daniele Ouellet (Merck & Co., Inc., USA; Janssen Research & Development, LLC, USA)
2. 单克隆抗体的皮下给药：药理学、输送、免疫原性及临床开发中的应用经验
Subcutaneous Administration of Monoclonal Antibodies: Pharmacology, Delivery, Immunogenicity, and Learnings From Applications to Clinical Development
作者：John D. Davis* (Regeneron Pharmaceuticals, Inc., USA)
3. 支持治疗蛋白新给药途径批准的临床药理学方法
Clinical Pharmacology Approaches to Support Approval of New Routes of Administration for Therapeutic Proteins
作者：Yow-Ming C. Wang* (OCP, Office of Translational Sciences, CDER, FDA, USA)

Research（研究）
1. 携带DPYD变异等位基因的患者接受局部5-氟尿嘧啶治疗的毒性风险
Risk of Toxicity From Topical 5-Fluorouracil Treatment in Patients Carrying DPYD Variant Alleles
作者：Javier Granados, Daniel L. Hertz* (University of Michigan College of Pharmacy, USA)

Articles（文章）
1. 用于指导成人和儿童双特异性T细胞引导剂静脉注射和皮下给药的基于生理学基础的药代动力学平台模型机制
A Mechanistic Physiologically-Based Pharmacokinetic Platform Model to Guide Adult and Pediatric Intravenous and Subcutaneous Dosing for Bispecific T Cell Engagers
作者：Xinwen Zhang, Vijay V. Upreti* (Clinical Pharmacology, Modeling, and Simulation, Amgen Inc., USA)
2. 在表皮生长因子受体Exon 20插入非小细胞肺癌中确定和确认推荐的二期剂量的Amivantamab
Determination and Confirmation of Recommended Ph2 Dose of Amivantamab in Epidermal Growth Factor Receptor Exon 20 Insertion Non-Small Cell Lung Cancer
作者：Nahor Haddish-Berhane* (Janssen Research & Development, LLC, USA)
3. 在肺动脉高压III期研究中，免疫原性对索塔塞普特药代动力学、疗效和安全性的影响
The Impact of Immunogenicity on the Pharmacokinetics, Efficacy, and Safety of Sotatercept in a Phase III Study of Pulmonary Arterial Hypertension
作者：Karen Liao* (Merck & Co., Inc., USA)
4. 基于模型的皮下注射尼伏利尤单抗剂量选择在晚期实体瘤患者中的应用
Model-Based Dose Selection of Subcutaneous Nivolumab in Patients with Advanced Solid Tumors
作者：Yue Zhao, Heather Vezina* (Bristol Myers Squibb, USA)
5. 皮下注射重组活化凝血因子VIIa（Marzeptacog Alfa）用于A型或B型血友病合并抑制物患者的出血事件按需治疗
Subcutaneous Marzeptacog Alfa (Activated) for On-Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors
作者：Alan Faraj, Ulrika S. H. Simonsson* (Uppsala University, Sweden)
6. 美沙酮和丁丙诺啡/纳洛酮阿片激动剂治疗随机临床试验中，通过生化验证的戒断情况的药物遗传学研究
Pharmacogenetics of Biochemically Verified Abstinence in an Opioid Agonist Therapy Randomized Clinical Trial of Methadone and Buprenorphine/Naloxone
作者：Intishar Kazi, Bernard Le Foll*, Rachel F. Tyndale* (University of Toronto,  Canada)
7. 欧洲医学教育关键药物清单：一项改良的德尔菲研究
The European List of Key Medicines for Medical Education: A Modified Delphi Study
作者：Erik M. Donker* (Amsterdam UMC, Vrije Universiteit, The Netherlands)
8. 定量系统毒理学建模指导急性髓系白血病患者中Emvododstat安全剂量选择
Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients
作者：Kyunghee Yang* (Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., USA)
9. 药物诱导的急性胰腺炎：利用美国食品药品监督管理局不良事件报告系统数据库进行的真实世界药物警戒研究
Drug-Induced Acute Pancreatitis: A Real-World Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database
作者：Dongxuan Li, Qian Du* (The Third Affiliated Hospital of Chongqing Medical University, China)
10. 血型抗原A携带者在无更多免疫相关不良事件的情况下展现出延长的无进展生存期
Blood Group Antigen A Carriers Exhibit an Extended Progression-Free Survival with no more Immune-Related Adverse Events
作者：Chen-Lin Xiao, Jian-Quan Luo* (the Second Xiangya Hospital, China)
11. 妊娠对人类烟酰胺药代动力学和代谢的影响
Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans
作者：Muluneh M. Fashe*, Craig R. Lee* (University of North Carolina at Chapel Hill,  USA)
12. 抗白介素-33抗体Tozorakimab在健康成人和慢性阻塞性肺病患者中的随机一期研究
A Randomized Phase I Study of the Anti-Interleukin-33 Antibody Tozorakimab in Healthy Adults and Patients With Chronic Obstructive Pulmonary Disease
作者：Fred Reid* (BioPharmaceuticals R&D, UK)
13. 撒哈拉以南非洲人群中CYP2B6和CYP2A6药物遗传变异的特征
Characterization of CYP2B6 and CYP2A6 Pharmacogenetic Variation in Sub-Saharan African Populations
作者：David Twesigomwe*, Scott Hazelhurst* (University of the Witwatersrand, South Africa)
14. 利用蛋白质组学指导的相对表达因子方法成功预测转运药物的人体肝脏浓度
Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics-Informed Relative Expression Factor Approach
作者：Mengyue Yin, Jashvant D. Unadkat* (University of Washington, USA)
15. ISABELA研究：血浆暴露量和靶向结合未能解释齐瑞他赛在特发性肺纤维化患者中缺乏疗效的原因
ISABELA Studies: Plasma Exposure and Target Engagement Do Not Explain the Lack of Efficacy of Ziritaxestat in Patients with Idiopathic Pulmonary Fibrosis
作者：Amit Taneja, Florence Namour* (Galapagos NV, The Netherlands; Galapagos SASU, France)
16. 利用全身生理学基础药代动力学模型结合心脏离子电流抑制评估奎尼丁诱发扭转型室性心动过速风险
Assessment of Quinidine-Induced Torsades de Pointes Risks Using a Whole-Body Physiologically Based Pharmacokinetic Model Linked to Cardiac Ionic Current Inhibition
作者：Zexin Zhang, Li Liu*, Xiaodong Liu* (China Pharmaceutical University, China)

二、药理学评论

March 2024 - Volume 76 - Issue 2 (2024年3月第76卷第2期)
https://pharmrev.aspetjournals.org/content/76/2

Review Articles（综述文章）
1. 细胞外囊泡作为神经性疾病“液体活检”的出现：繁荣还是泡沫
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust
作者：Ashish Kumar, Andrew Baker* (Wake Forest University School of Medicine, USA; Medical Center Boulevard, USA)
2. 利用淋巴系统靶向策略改善系统性红斑狼疮的临床疗效
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes
作者：K.T. Babalola, Francesca Levi-Schaffer* (Alabama Life Research Institute, and The University of Alabama, USA; The University of Alabama, USA)
3. 保护人类与动物健康：从动物模型到新方法途径
Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods
作者：Barbara L.F. Kaplan, Charles France* (Mississippi State University, USA)
4. G蛋白偶联受体及其受体激酶在胰岛β细胞功能和糖尿病中的作用
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes
作者：Matthew J. Varney, Martin Michel* (Thomas Jefferson University, USA)
5. 芳香胺N-乙酰转移酶作为与线粒体功能障碍相关的代谢性疾病治疗靶点
The Arylamine N-Acetyltransferases as Therapeutic Targets in Metabolic Diseases Associated with Mitochondrial Dysfunction
作者：Chandra Choudhury, Michael Gottesman* (University of Queensland, Australia)

三、先进药物输送评论 (2024年第206卷)

March 2024 - Volume 206 (2024年3月第206卷)
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/206/suppl/C

Review article（综述文章）
1. 超声响应性微泡与纳米液滴：通往靶向药物递送的途径
Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery
作者：Gazendra Shakya, Outi Supponen* (Institute of Fluid Dynamics, D-MAVT, Switzerland)
2. mRNA递送系统在癌症免疫治疗中的应用：脂质纳米颗粒及其他递送平台
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond
作者：Mariona Estapé Senti, Raymond M. Schiffelers* (University Medical Center Utrecht, the Netherlands)
3. 使用弹性蛋白样多肽进行生物活性纳米粒子的立体稳定化
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides
作者：Alvin Phan, J. Andrew MacKay* (University of Southern California, USA)
4. 通过局部药物递送实现自身免疫型1型糖尿病细胞移植的免疫保护
Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery
作者：T.R. Lansberry, C.L. Stabler (University of Florida,  USA)
5. 从概念到早期临床试验：30年的微泡基超声介导药物递送研究
From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research
作者：Ayache Bouakaz* (Université de Tours, France)

四、药理学发展趋势 (2024年第45卷第3期)

March 2024 - Volume 45 - Issue 3 (2024年3月第45卷第3期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(23)X0004-2

Spotlight（聚焦）
1. 心脏肌肉粗丝的复杂结构被揭示
Complex architecture of cardiac muscle thick filaments revealed
作者：Pradeep K. Luther* (Imperial College London,  UK)

Forum（论坛）
1. 针对PWWP结构域的抑制剂开发进展
Advances in inhibitor development targeting the PWWP domain
作者：Yunyuan Huang, Jinrong Min* (Central China Normal University, China)

Opinion（意见）
1. 阿尔茨海默病治疗进展：从神经退行到神经再生的转变
Alzheimer’s therapeutic development: shifting neurodegeneration to neuroregeneration
作者：Miao-Kun Sun* (Synaptogenix, Inc., USA)

Reviews（综述）
1. 针对癌症中的染色体不稳定性与非整倍体
Targeting chromosomal instability and aneuploidy in cancer 
作者：Sugandha Bhatia*, Pascal H.G. Duijf* (Centre for Genomics and Personalised Health and Centre for Biomedical Technologies at the Translational Research Institute, Australia)
2. 线粒体DNA竞争：饿死突变基因组
Mitochondrial DNA competition: starving out the mutant genome
作者：Antonella Spinazzola*, Ian J. Holt* (UCL Queen Square Institute of Neurology, UK)
3. 组蛋白赖氨酸乙酰转移酶抑制剂：癌症治疗中新兴的药物类别
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy 
作者：Jeffrey White, Thomas A. Paul* (Pfizer Inc., Oncology Research Unit, USA)
4. 生成生物学在生物治疗发现中的最近进展
Recent advances in generative biology for biotherapeutic discovery
作者：Marissa Mock, Alan Russell* (Amgen Research, Amgen Inc., USA)
5. 嗅觉受体的结构与功能
The structure and function of olfactory receptors
作者：Chenyang Wu, Marc Xu, Shuguang Yuan* (The AlphaMol-SIAT Joint Laboratory, China)

五、药理学与治疗学 (2024年第255卷)

March 2024 - Volume 254 (2024年3月第255卷)
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/255/suppl/C

Review article（综述文章）
1. 非典型G蛋白信号传导
Non-canonical G protein signaling
作者：Bernd Nürnberg* (Institute of Experimental and Clinical Pharmacology and Pharmacogenomics, Germany)
2. 微胶质细胞异质性在突触可塑性与脑疾病中的作用：测序研究能否揭示新的治疗靶点？
The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?
作者：Yi You, Wei-Wei Hu* (Zhejiang University School of Medicine, China)
3. 富含蛋白质的食物、海鲜和肠道菌群增强慢性疾病和癌症的免疫反应——靶向PERK作为慢性炎症性疾病、神经退行性疾病和癌症的新型治疗策略
Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers – Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases,neurodegenerative disorders, and cancer
作者：Fatma Saaoud, Xiaofeng Yang* (Temple University Lewis Katz School of Medicine, USA)

六、药物 (2024年第84卷第3期)

March 2024 - Volume 84 - Issue 3 (2024年3月第84卷第3期)
https://link.springer.com/journal/40265/volumes-and-issues/84-3

Review Article（综述文章）
1. 成人起病型斯蒂尔病（AOSD）：病理生理学、遗传学认识的进步和新兴治疗选择
Adult-Onset Still’s Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options
作者：Sara Bindoli, Paolo Sfriso* (University of Padova, Italy)
2. 微囊化苯甲酸过氧化氢在玫瑰痤疮治疗中的应用：当前治疗格局的综述
Microencapsulated Benzoyl Peroxide for Rosacea in Context: A Review of the Current Treatment Landscape
作者：Seemal R. Desai, Jean Philippe York* (Innovative Dermatology, USA; Galderma Laboratories, USA)
3. 靶向多发性硬化症中CD20的药物：药理学、疗效、安全性和耐受性
Drugs Targeting CD20 in Multiple Sclerosis: Pharmacology, Efficacy, Safety, and Tolerability
作者：Alise K. Carlson, Jeffrey A. Cohen* (Cleveland Clinic, USA)

Systematic Review（系统综述）
1. 阿片类药物用于急性肌肉骨骼疼痛：一项系统评价与元分析
Opioids for Acute Musculoskeletal Pain: A Systematic Review with Meta-Analysis
作者：Caitlin M. P. Jones* (The University of Sydney and Sydney Local Health District, Australia)

Adis Drug Evaluation（Adis药物评估报告）
1. 沃诺拉赞：幽门螺杆菌感染治疗中的评估
Vonoprazan: A Review in Helicobacter pylori Infection
作者：Matt Shirley* (Springer Nature, New Zealand)
2. SER-109（VOWST™）：预防复发性艰难梭菌感染的评估
SER-109 (VOWST™): A Review in the Prevention of Recurrent Clostridioides difficile Infection
作者：Hannah A. Blair* (Springer Nature, New Zealand)

AdisInsight Report（AdisInsight报告）
1. Capivasertib：首次获批
Capivasertib: First Approval
作者：Matt Shirley* (Springer Nature, New Zealand)
2. Lebrikizumab：首次获批
Lebrikizumab: First Approval
作者：Susan J. Keam* (Springer Nature, New Zealand)
3. Nirogacestat：首次批准
Nirogacestat: First Approval
作者：Susan J. Keam* (Springer Nature, New Zealand)
4. 10.3% 贝达西米局部凝胶：首次批准
Berdazimer Topical Gel, 10.3%: First Approval
作者：Susan J. Keam* (Springer Nature, New Zealand)

七、药理学研究 (2024年第201卷)

March 2024 - Volume 201 (2024年3月第201卷)
https://www.sciencedirect.com/journal/pharmacological-research/vol/201/suppl/C

Review Articles（综述文章）
1. IUPHAR ECR综述：cGAS-STING通路：超越先天免疫的新颖功能与新兴治疗机遇
IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities
作者：Xu He¹, Abdalla Wedn², Jian Wang³, Renpeng Zhou⁴*, Xiaocong Pang¹*, Yimin Cui¹* (1. Peking University First Hospital, China; 2. University of Pittsburgh, USA; 3. Tianjin’s Clinical Research Center for Cancer, China; 4. The Second Affiliated Hospital of Anhui Medical University, China)
2. 药物递送系统中的生物制品、治疗诊断学和个性化医学
Biologics, theranostics, and personalized medicine in drug delivery systems
作者：Matteo Puccetti*, Maurizio Ricci* (University of Perugia, Italy)
3. 白细胞介素-18在慢性疼痛中的作用：关注致病机制和潜在治疗靶点
Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets
作者：Jie Ju, Feng Gao* (Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China)
4. 影响肝脏和心脏的代谢性疾病：基于miRNA的治疗疗效？
Metabolic disorders affecting the liver and heart: Therapeutic efficacy of miRNA-based therapies?
作者：Lucia La Sala* (University of Milan, Italy)
5. 癌症中异常内质网运输途径的作用洞察：从癌症标志的视角
Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks
作者：Hongjie Guo, Ling Ding*, Bo Yang* (Zhejiang University, China)
6. 通过调节神经可塑性对抑郁症的治疗作用：从分子机制到潜在的临床应用
The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications
作者：Shen Chen, Hui Dong*, Zhi Wang* (Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China)
7. 阿尔茨海默病和帕金森病中的VEGFs/VEGFRs系统：病理生理作用与治疗意义
The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications
作者：Claudia Ceci, Grazia Graziani* (University of Rome Tor Vergata, Italy)
8. 医学中的异硫氰酸酯：关于苯乙基、烯丙基和苄基异硫氰酸酯的综述
Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
作者：Cosima C. Hoch, Barbara Wollenberg* (Technical University of Munich (TUM), Germany)
9. 天然产品的新型纳米药物递送系统及其应用
Novel nano-drug delivery system for natural products and their application
作者：Li Huang¹, Xue-Hua Huang¹, Pei-Yu Yan¹*, Ying Xie²* (1. Macau University of Science and Technology, China; 2.  The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China)

Research article（研究文章）
1. 高血糖和慢性应激在小鼠海马中的“西海岸摇摆”危险舞蹈：犬尿氨酸代谢的作用
The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism
作者：Micaela Gliozzi*, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino* (University Magna Græcia of Catanzaro, Italy)
2. 脂联素2（LCN2）通过LCN2-MMP-9信号通路在非小细胞肺癌中赋予阿蒙替尼耐药性
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway
作者：Chen Shi, Cong Wang, Yu Zhang* (Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China)
3. 青少年抑郁症的新快速治疗选择
Novel rapid treatment options for adolescent depression
作者：Sandra Ledesma-Corvi, M. Julia García-Fuster* (University of the Balearic Islands, Spain)
4. 新的Ref-1/APE1靶向抑制剂在多种癌症类型中展示出改善的效力以用于临床应用
New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types
作者：Silpa Gampala, Melissa L. Fishel* (Indiana University School of Medicine, USA)
5. 通过增加洞穴激活，SHP2的变构抑制剂增强了巨噬细胞的内吞作用和细菌清除，并保护免受细菌性败血症的侵害
Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
作者：Tianliang Li¹, Bing Xu², Wenqian Li³, Liming Zhao⁴*, Nan Li¹*, Chaofeng Han¹* (1. Institute of Immunology, Naval Medical University, China; 2. School of Anesthesiology, Naval Medical University, China; 3. Zhongshan Hospital, Fudan University, China; 4. Dongfang Hospital, Tongji University, China)
6. MicrobeTCM——一个微生物群与传统中医药相互作用的综合平台
MicrobeTCM: A comprehensive platform for the interactions of microbiota and traditional Chinese medicine
作者：Yufeng Chen, Yu Shi, Chengbang Liang, Jianxin Chen*, Qian Hua* (Beijing University of Chinese medicine, China)
7. 来自Pristimerin的天然五环三萜类化合物通过泛素化Chk1使p53缺陷的肿瘤对PARP抑制剂敏感
Natural pentacyclic triterpenoid from Pristimerin sensitizes p53-deficient tumor to PARP inhibitor by ubiquitination of Chk1
作者：Li Tao*, Xiangyu Xia, Weimin Wang* (Yangzhou University, China)
8. 纳米粒子和siRNA：治疗学的新纪元？
Nanoparticles and siRNA: A new era in therapeutics?
作者：María Dolores Pérez-Carrión, Valentín Ceña* (Universidad de Castilla-La Mancha, Spain)
9. 单细胞和空间转录组学揭示了PTPRG激活m6A甲基转移酶VIRMA以阻断阿尔茨海默病中的线粒体自噬介导的神经元死亡
Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer’s disease
作者：Donghua Zou¹, Xiaohua Huang², Yating Lan¹, Mika Pan¹, Jieqiong Xie¹, Cuihua Zou³*, Yingwei Mao⁴*, Jiefeng Luo¹* (1. The Second Affiliated Hospital of Guangxi Medical University, China; 2. The Affiliated Hospital of Youjiang Medical University for Nationalities, China; 3. Guangxi Medical University Cancer Hospital, China; 4. Pennsylvania State University, USA)
10. CDK12抑制通过AKT/FOXO3途径上调ATG7触发自噬并增强结直肠癌中抗PD-1疗效
CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer
作者：Zimei Wu¹, Wenxin Zhang¹, Xiang Mao²*, Haifei Chen¹*, Qunyi Li¹* (1. Department of Pharmacy, Huashan Hospital, Fudan University, China; 2. Department of Surgery, Huashan Hospital, Fudan University, China)
11. ACOX1缺乏引起的脂质代谢紊乱促进肾移植后慢性间质纤维化的发展
ACOX1 deficiency-induced lipid metabolic disorder facilitates chronic interstitial fibrosis development in renal allografts
作者：Yang-He Zhang¹, Honglan Zhou²*, Zhi-Xiang Xu¹*, Yishu Wang¹* (1. Jilin University, China; 2. The First Hospital of Jilin University, China)

八、抗病毒研究 (2024年第223卷)

March 2024 - Volume 223 (2024年3月第223卷)
https://www.sciencedirect.com/journal/antiviral-research/vol/223/suppl/C

Research article（研究文章）
1. 肽类模拟物对细胞培养中乙型肝炎病毒感染的抗病毒效果
Antiviral effect of peptoids on hepatitis B virus infection in cell culture
作者：Asako Murayama, Takanobu Kato* (National Institute of Infectious Diseases, Japan)
2. 人神经前体细胞模型用于研究获批和在研的人类巨细胞病毒抑制剂的抗病毒效果和神经保护潜力
Human neural progenitor cell models to study the antiviral effects and neuroprotective potential of approved and investigational human cytomegalovirus inhibitors
作者：Marta Trevisan*, Beatrice Mercorelli*, Arianna Loregian* (University of Padua, Italy)
3. 米特福辛通过增强STAT3激活减少小鼠的柯萨奇病毒B3致死性
Miltefosine reduces coxsackievirus B3 lethality of mice with enhanced STAT3 activation
作者：Chun Yu Zhang¹, Li-Chiu Wang²*, Shih-Min Wang³*, Shun-Hua Chen¹* (1. Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Taiwan, China; 2. Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan, China; 3. Center for Infection Control, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan, China)
4. 药物再利用平台用于解析可药用的SARS-CoV-2相互作用组
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome
作者：Mariia S. Bogacheva* (University of Helsinki, Finland)
5. 用于评估由抗逆转录病毒药物引起的高脂血症风险的脂质指数
A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs
作者：Mari Shimura¹*, Nobuyo Higashi-Kuwata², Hiroaki Mitsuya²* (1. Research Institute, National Center for Global Health and Medicine, Japan; 2. Department of Refractory Viral Diseases, National Center for Global Health and Medicine, Japan)
6. 基于猫冠状病毒N蛋白的腺病毒载体疫苗引发强烈的保护性免疫反应
An adenovirus-vectored vaccine based on the N protein of feline coronavirus elicit robust protective immune responses
作者：Yuanhong Wang, Lingxue Yu*, Guoxin Li*, Guangqing Liu* (Chinese Academy of Agricultural Sciences, China)
7. 鉴定和评估1,6-二羟基-吡啶-2-酮基团作为乙型肝炎病毒核糖核酸酶H抑制的特许支架
Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition
作者：Erofili Giannakopoulou, Grigoris Zoidis* (National and Kapodistrian University of Athens, Greece)
8. 与猪IgG-Fc结合的猪干扰素-α诱导针对口蹄疫病毒的持久和广谱抗病毒效果
Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus
作者：Gyeongmin Lee, Su-Mi Kim* (Animal and Plant Quarantine Agency, Republic of Korea)
9. 莫努匹韦在3D人肠类器官中抑制人类诺如病毒和轮状病毒复制
Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
作者：Nanci Santos-Ferreira, Joana Rocha-Pereira* (Rega Institute, Laboratory of Virology and Chemotherapy, Belgium)
10. 作为强效新型流感病毒进入抑制剂的芹菜酸的发现
Discovery of cyperenoic acid as a potent and novel entry inhibitor of influenza A virus
作者：Xiaoli Zhang¹, Yiping Xia², Wei Tang²*, Weiwei Su¹* (1. Sun Yat-sen University, China; 2. Jinan University, China)
11. 针对SARS-CoV-2的治疗性抗体及其他替代疗法
Therapeutic antibodies and alternative formats against SARS-CoV-2
作者：Rahel R. Winiger, Rahel R. Winiger* (University of Lausanne (UNIL), Lausanne University Hospital (CHUV), Service of Immunology and Allergy, and Center for Human Immunology Lausanne (CHIL), Switzerland)
12. 揭示分泌型IgA在防护呼吸道病毒感染中的潜力与关键作用
Unmasking the potential of secretory IgA and its pivotal role in protection from respiratory viruses
作者：Divya Sinha, Stéphane Paul*, Stéphanie Longet* (Université Claude Bernard Lyon 1, France)

九、英国药理学杂志 (2024年第181卷第5-6期)

(一) March 2024 - Volume 181 - Issue 5 (2024年3月第181卷第5期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/5

Review Article（综述文章）
1. 酒精使用障碍中的孤儿肽和G蛋白偶联受体信号传导
Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder
作者：Roberta Goncalves Anversa, Leigh C. Walker* (Florey Institute of Neuroscience and Mental Health, Australia)

Invited Review（特约综述）
1. 人体气道平滑肌的体外和离体研究在慢性阻塞性呼吸道疾病治疗药物开发中的应用
Use of human airway smooth muscle in vitro and ex vivo to investigate drugs for the treatment of chronic obstructive respiratory disorders
作者：Luigino Calzetta* (University of Parma, Italy)

Research Articles（研究文章）
1. 巨噬细胞miR-204的双重作用限制了环孢素A诱导的动脉粥样硬化
Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis
作者：Jia-Hui Su¹, Tao Ban²*, Si-Jia Liang¹* (1. Sun Yat-Sen University, China; 2. Harbin Medical University, China)
2. Hsp70-Bim非相干正反馈环路促进细胞命运多样性与部分细胞杀伤
Hsp70-Bim incoherent feedforward loop contributes to cell-fate heterogeneity and fractional killing
作者：Fangkui Yin, Ting Song*, Zhichao Zhang* (Dalian University of Technology, China)
3. 在转化性大鼠模型中，氟氯西林加剧而亚胺培南-西司他丁保护肾脏免受万古霉素诱导的肾脏损伤
Flucloxacillin worsens while imipenem–cilastatin protects against vancomycin-induced kidney injury in a translational rat model
作者：Gwendolyn M. Pais, Marc H. Scheetz* (Midwestern University-Downers Grove Campus, USA)
4. 黄芪多糖通过芳香烃受体依赖的自噬机制保护实验性结肠炎
Astragalus polysaccharide protects experimental colitis through an aryl hydrocarbon receptor-dependent autophagy mechanism
作者：Yi Ying¹, Jin-yuan Yan²*, Zhong-shan Yang¹* (1. Yunnan University of Chinese Medicine, China; 2. Kunming Medical University Second Hospital, China)
5. 鉴定药理学上11β-羟基类固醇脱氢酶1抑制的人类血液生物标志物
Identification of a human blood biomarker of pharmacological 11β-hydroxysteroid dehydrogenase 1 inhibition
作者：Cristina Gómez, Alex Odermatt* (University of Basel, Switzerland)
6. DADLE通过抑制脊髓损伤后细胞质磷脂酶A2介导的溶酶体膜通透性增加促进运动功能恢复
DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A2 mediated lysosomal membrane permeabilization after spinal cord injury
作者：Yituo Chen¹, Jian Xiao²*, Wenfei Ni¹*, Kailiang Zhou¹* (1. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China; 2. Wenzhou Medical University, China)
7. RALY通过在初级感觉神经元中触发Eif4g2基因表达参与神经损伤诱导的痛觉过敏
RALY participates in nerve trauma-induced nociceptive hypersensitivity through triggering Eif4g2 gene expression in primary sensory neurons
作者：Lina Huang, Yuan-Xiang Tao* (The State University of New Jersey, USA)

(二) March 2024 - Volume 181 - Issue 6 (2024年3月第181卷第6期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/6

Editorial（社论）
1. 从阿尔茨海默病到血管性痴呆：通往认知衰退的不同道路
From Alzheimer's disease to vascular dementia: Different roads leading to cognitive decline
作者：Aurora Semerano, Marta Cortes-Canteli*, María A. Moro* (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Spain)

Themed Issue Review（主题刊综述）
1. 口服抗凝剂：阿尔茨海默病的一种可能的新疗法？
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?
作者：Raquel Toribio-Fernandez, Marta Cortes-Canteli* (Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Spain)
2. 血管性痴呆和阿尔茨海默病中的髓系细胞：可能的治疗靶点？
Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?
作者：Alicia García-Culebras*, María Ángeles Moro* (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Spain)
3. T细胞在认知障碍中作用的最新进展
Update on the role of T cells in cognitive impairment
作者：Ignacio Ruiz-Fernández, Pilar Martín* (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
4. 肠道微生物群在脑血管疾病及相关痴呆中的作用
The role of gut microbiota in cerebrovascular disease and related dementia
作者：María Isabel Cuartero*, María Ángeles Moro* (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
5. 脂肪组织作为阿尔茨海默病血管损伤治疗的靶点
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
作者：Miriam Bettinetti-Luque, David Baglietto-Vargas* (Universidad de Málaga, Spain)
6. 脑血管疾病功能障碍与tau病变之间的联系机制：增加一层表观调控复杂性
Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity
作者：Yoon A. Kim, Ismael Santa-Maria* (Columbia University, USA)

Themed Issue Article（主题刊文章）
1. 星形胶质细胞源性乳铁蛋白通过促进雄性APP/PS1转基因小鼠中p38激酶与PP2A磷酸酶之间的相互作用减少β-淀粉样蛋白负担
Astrocyte-derived lactoferrin reduces β-amyloid burden by promoting the interaction between p38 kinase and PP2A phosphatase in male APP/PS1 transgenic mice
作者：Yong-Gang Fan, Zhan-You Wang* (Health Sciences Institute of China Medical University, China)

十、临床药代动力学 (2024年第63卷第3期)

March 2024 -Volume 63 - Issue 3 (2024年3月第63卷第3期)
https://link.springer.com/journal/40262/volumes-and-issues/63-3

Current Opinion（当今观点）
1. 唾液治疗药物监测在抗微生物治疗中的应用：可行还是徒劳？
Salivary Therapeutic Drug Monitoring of Antimicrobial Therapy: Feasible or Futile?
作者：Lina Davies Forsman, Jan-Willem C. Alffenaar* (Karolinska Institute, Sweden; University of Sydney, Australia)

Systematic Review（系统综述）
1. 走向利伐沙班的基因检测？来自系统综述的见解：基因多态性在利伐沙班治疗中的作用
Toward Genetic Testing of Rivaroxaban? Insights from a Systematic Review on the Role of Genetic Polymorphism in Rivaroxaban Therapy
作者：Yi Ma¹, Zaiwei Song¹, Rongsheng Zhao¹*, Zhanmiao Yi²* ( 1. Peking University Third Hospital, China; 2. Peking University Health Science Center, China)

Original Research Article（原创研究文章）
1. HRS-2261，一种P2X3受体拮抗剂，在健康受试者中的安全性和药代动力学：一项随机、双盲、安慰剂对照的I期研究
Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
作者：Yuru Fan, Xuan Zhang, Qian Zhang*, Wei Hu* (The Second Affiliated Hospital of Anhui Medical University, China)
2. 人群药代动力学/药效学模型在P2Y12抑制剂中的应用：利用暴露模拟进行系统评价和临床评估
Population Pharmacokinetic/Pharmacodynamic Models for P2Y12 Inhibitors: A Systematic Review and Clinical Appraisal Using Exposure Simulation
作者：Jingcheng Chen, Cheng Cui*, Dongyang Liu* (Peking University Third Hospital, Beijing, China)
3. 在母乳中测量的母体依泽替米浓度及其在母乳喂养婴儿暴露预测中的应用
Maternal Ezetimibe Concentrations Measured in Breast Milk and Its Use in Breastfeeding Infant Exposure Predictions
作者：Cindy H. T. Yeung, Andrea N. Edginton* (Hospital for Sick Children, Canada; University of Waterloo, Canada)
4. 儿童囊性纤维化患者中Lumacaftor/Ivacaftor的群体药代动力学：迈向个体化治疗的第一步
Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy
作者：Naïm Bouazza* (Université Paris Cité, France)
5. 为提高基于生理药代动力学模型预测性能的评估稳健性：使用置信区间支持临床监护中模型指导剂量的使用
Towards More Robust Evaluation of the Predictive Performance of Physiologically Based Pharmacokinetic Models: Using Confidence Intervals to Support Use of Model-Informed Dosing in Clinical Care
作者：Marjolein D. van Borselen*, Laurens Auke Æmiel Sluijterman (Radboud University Medical Center, The Netherlands; Radboud University Nijmegen, The Netherlands)
6. 镰状细胞病患者L-谷氨酰胺暴露的群体药代动力学分析：剂量和食物效应的评估
A Population Pharmacokinetic Analysis of L-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects
作者：Alina Sadaf, Charles T. Quinn* (Cincinnati Children’s Hospital Medical Center, USA)
7. 贝叶斯万古霉素模型选择用于新生儿治疗药物监测
Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates
作者：Dua’a Alrahahleh, Jan-Willem Alffenaar* (The University of Sydney, Australia)
8. 超越界限：利用纵向暴露-反应模型为有界结果评分提供决策信息以加速药物开发范式
Moving Beyond Boundaries: Utilization of Longitudinal Exposure–Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm
作者：Yeamin Huh* (Pfizer Inc, USA)